Evidence map›Paper›PMID 40116487›Full record

ArticleInfection and immunity2025

A CRISPRi library screen in group B

K Firestone, K P Gopalakrishna, L M Rogers, A Peters, J A Gaddy, C M Nichols, M H Hall, H N Varela, S M Carlin, G H Hillebrand and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

K Firestone *Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
K P Gopalakrishna *Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.
L M RogersDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
A PetersDietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J A GaddyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
C M NicholsDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
M H HallDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
H N VarelaDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
S M CarlinDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
G H HillebrandProgram in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
E J GiacobeProgram in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
D M AronoffDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
T A HoovenDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1959-186X

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
Determining the contribution of zinc deficiency to perinatal Group B Streptococcus infectionsR01HD090061 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M, GADDY, JENNIFER A · 2017 to 2021
$2.5M
The Role of macrophages in chorioamnionitis and group B streptococcal infectionsR01AI134036 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M · 2017 to 2021
$2.4M
Group B Streptococcus surface determinants of neonatal intestinal colonization and infectionR01AI182835 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas A Hooven · 2024 to 2026
$1.6M
Signal transduction, metabolic shifts, and host interactions during group B Streptococcus infectionR01AI177991 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas A Hooven · 2024 to 2026
$1.4M
Utility of human milk oligosaccharides against the perinatal pathogen, Group B StreptococcusR01HD113675 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer A Gaddy, Steven D. Townsend · 2024 to 2026
$1.1M
Genome-wide assessment of Group B Streptococcus fitness and virulenceR21AI147511 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOOVEN, THOMAS A, RATNER, ADAM JONATHAN · 2020 to 2021
$489k
Bacterial CRISPR interference to define macrophage responses to group B Streptococcus proteinsR21AI178067 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ARONOFF, DAVID M, HOOVEN, THOMAS A · 2023 to 2024
$451k
BLRD VA I01 BX005352BLRD VA I01 BX007005Burroughs Wellcome Fund 1275387March of Dimes Foundation 6-FY24-0009NIAID NIH HHS R01 AI134036NIAID NIH HHS R01 AI177991NIAID NIH HHS R01 AI182835NIAID NIH HHS R21 AI147511NIAID NIH HHS R21 AI178067NICHD NIH HHS R01 HD090061NICHD NIH HHS R01 HD113675NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NIH HHS R01AI134036NIH HHS R01AI182835,R01AI177991NIH HHS R01HD090061,R01HD113675NIH HHS R21AI178067NIH HHS T32GM007347,T32GM152284U.S. Department of Veterans Affairs I01BX005352,I01BX007005
6 · The paper itself

Abstract

Group B

Indexed as

Bacterial ProteinsHost-Pathogen InteractionsMembrane ProteinsStreptococcal InfectionsStreptococcus agalactiaeAnimalsBiofilmsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsCytokinesFemaleHumansInterleukin-1betaMacrophagesMiceBacterial ProteinsCytokinesInterleukin-1betaMembrane ProteinsCRISPR interferencecytokine responseGroup B Streptococcushost-pathogen interactionssurface proteins

Identifiers

PMID40116487
PMCPMC11977309

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.