Evidence map›Paper›PMID 40116460›Full record

Trial reportJournal of the European Academy of Dermatology and Venereology : JEADV2026

Passive versus active educational interventions for nevus and melanoma classification: A randomized controlled study.

M Spadafora, R Pampena, K Peris, L Del Regno, L Cornacchia, M C Fargnoli, C Pellegrini, P Quaglino, S Ribero, P G Calzavara-Pinton and 8 more

Abstract readRandomized Controlled TrialMulticenter StudyComparative Study
In one paragraph

Trial report in Journal of the European Academy of Dermatology and Venereology : JEADV, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Passive versus active educational interventions for nevus and melanoma classification: A randomized controlled study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Trial
  2. Towards evidence-based policy in melanoma screening and skin self-examination education.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

M SpadaforaAzienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Skin Cancer Center, Reggio Emilia, Italy.ORCID https://orcid.org/0000-0003-3509-4222
R PampenaPrivate Practice, Formia, Italy.ORCID https://orcid.org/0000-0002-7699-879X
K PerisDepartment of Translational Medicine and Surgery, IRCCS A. Gemelli, Sacred Heart Catholic University, Rome, Italy.ORCID https://orcid.org/0000-0003-1957-6600
L Del RegnoDermatology, Dipartimento di Medicina e Chirurgia Traslazionale, Sacred Heart Catholic University, Rome, Italy.
L CornacchiaDepartment of Translational Medicine and Surgery, IRCCS A. Gemelli, Sacred Heart Catholic University, Rome, Italy.
M C FargnoliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.ORCID https://orcid.org/0000-0002-7249-2556
C PellegriniDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
P QuaglinoDermatologic Clinic, Department of Medical Sciences, University of Turin, Turin, Italy.ORCID https://orcid.org/0000-0003-4185-9586
S RiberoDermatologic Clinic, Department of Medical Sciences, University of Turin, Turin, Italy.ORCID https://orcid.org/0000-0002-0098-1406
P G Calzavara-PintonDepartment of Dermatology, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-0935-7204
M C ArisiDepartment of Dermatology, University of Brescia, Brescia, Italy.
M MirraAzienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Skin Cancer Center, Reggio Emilia, Italy.
M RaucciAzienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Skin Cancer Center, Reggio Emilia, Italy.
A FuscoAzienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Skin Cancer Center, Reggio Emilia, Italy.
S KaleciDepartment of Surgery, Medicine, Dental Medicine and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
J ChesterDepartment of Surgery, Medicine, Dental Medicine and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID https://orcid.org/0000-0003-2866-0783
G PellacaniDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
C LongoAzienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Skin Cancer Center, Reggio Emilia, Italy.ORCID https://orcid.org/0000-0002-8218-3896

Funding

Società Italiana Dermatologia e Malattie Sessualmente Trasmesse (SiDeMaST) 184/2019/SPER/IRCCSRE
6 · The paper itself

Abstract

backgroundsPatients or family members first notice around 50% of primary melanoma lesions. Targeted educational campaigns for non-medical individuals improve melanoma detection rates, but the most effective initiatives are unclear.

objectivesTo compare the efficacy of passive versus active intervention for non-medical individuals in classifying nevi and melanomas.

methodsA multicentric randomized controlled study randomly assigned subjects to receive active intervention (a dermatologist explaining basic rules for melanoma detection) or passive intervention (subject independently reading the basic rules). Subjects were asked to classify 60 clinical photos of nevi and melanomas as 'at risk' of malignancy and nominated the rule(s) they applied at 3 time points-before (T0), immediately following (T1), and 30 ± 2 days after (T2) the educational intervention.

resultsWe randomized 364 patients. We included in the analysis 336 subjects (female 61.3%, 156 in the passive and 180 in the active intervention group) with a mean age of 44.5 years. Overall, detection rates of lesions 'at risk' improved from 71.2% (T0) to 86.4% (T1). At T2, detection rates were significantly higher after active intervention (83.7% vs. 86.8%, p = 0.017). Although an overall improvement was described after both interventions, rates of correct responses according to lesion-specific features were significantly higher in the active intervention group for lesions that met ugly duckling (UD) rule criteria at T1 and both rules (ABCDE and UD rules) criteria at T2. Correct (full or partial) rule applications were observed in 80% at T1 (40.2% and 38.4%, respectively) and at T2 (40.4% and 37.8%, respectively), with significantly higher correct rule application in the active group at T1 (p = 0.001) and T2 (p = 0.03).

conclusionsActive educational intervention is more effective than passive education in improving nevi and melanomas classification and correct rule application in non-medical individuals, with stable performance observed over time.

Indexed as

MelanomaNevusPatient Education as TopicSkin NeoplasmsAdultFemaleHumansMaleMiddle Aged

Identifiers

PMID40116460
PMCPMC12723570

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.