Evidence map›Paper›PMID 40116383›Full record

ArticleJournal of the American College of Surgeons2025

Beyond the Neck: When Is Thoracic Operation Needed for Thyroidectomy?

Rongzhi Wang, Zhixing Song, Sanjana Balachandra, Andrea Gillis, Jessica Fazendin, Brenessa Lindeman, Benjamin Wei, Herbert Chen

Abstract read
In one paragraph

Article in Journal of the American College of Surgeons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rongzhi WangFrom the Department of Surgery, University of Alabama at Birmingham, Birmingham, AL.
Zhixing Song
Sanjana Balachandra
Andrea Gillis
Jessica Fazendin
Brenessa Lindeman
Benjamin Wei
Herbert Chen

Funding

Surgical Oncology Research Training ProgramT32CA229102 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HERBERT CHEN · 2018 to 2026
$3.2M
NCI NIH HHS T32 CA229102
6 · The paper itself

Abstract

backgroundAlthough most patients with intrathoracic thyroid glands can undergo thyroidectomy via a cervical incision, some cases necessitate intraoperative thoracic surgery assistance. This study aimed to identify CT findings that predict the need for thoracic surgery assistance during thyroidectomy. STUDY

designWe reviewed administrative data at our institution (2012 to 2023), encompassing 7,370 thyroidectomies, to identify patients who underwent thyroidectomy for intrathoracic thyroid glands, defined as thyroid glands that extended below the sternal notch. Detailed CT analysis was conducted, including measurements of intrathoracic thyroid dimensions, shape, extension to posterior mediastinum, and relation to thoracic inlet. Receiver operating characteristic curve analysis and multivariable regression analysis were performed to identify the most accurate independent predictors of the need for intraoperative thoracic surgery assistance.

resultsAmong 255 patients with intrathoracic thyroid glands, 34 (13.3%) required intraoperative thoracic surgery assistance. Patients needing thoracic assistance had significantly larger intrathoracic thyroid glands in anteroposterior, craniocaudal, and horizontal dimensions compared with those without. Additionally, their thyroid glands were more likely to enlarge below the sternal notch or extend into the posterior mediastinum receiver operating characteristic curve indicated that distance from inferior border of thyroid gland to sternal notch (area under curve [AUC] = 0.94) is a better predictor than distance to aortic arch (AUC = 0.91) or sternal angle (AUC = 0.91). Thresholds of distance to sternal notch 5.3 cm or more, anteroposterior dimension 5.2 cm or more, and horizontal dimension 5.3 cm or more provided 80% sensitivity and 70% or more specificity for predicting the need for thoracic assistance. Multivariable regression analysis identified thyroid increasing in size below sternal notch, distance to sternal notch 5.3 cm or more, and horizontal dimension 5.3 cm or more as independent predictors for intraoperative thoracic assistance.

conclusionsThyroid glands extending 5.3 cm or more below sternal notch, enlarging below sternal notch, or having a horizontal dimension 5.3 cm or more warrant preoperative thoracic surgery consultation for potential intraoperative assistance.

Indexed as

Thoracic Surgical ProceduresThyroidectomyThyroid GlandAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesROC CurveTomography, X-Ray Computed

Identifiers

PMID40116383
PMCPMC12276953

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.