ArticleVeterinary dermatology2025
A blinded randomised split-body clinical trial evaluating the effect of fluorescent light energy on antimicrobial management of canine interdigital furunculosis.
Article in Veterinary dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical practice recommendations and expected outcomes with fluorescent light energy: a Delphi-like consensus.BMC veterinary research · 2025Article
- A blinded randomised split-body clinical trial evaluating the effect of fluorescent light energy on antimicrobial management of canine interdigital furunculosis.Veterinary dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundCanine interdigital furunculosis (CIF) is a complex, relapsing inflammatory condition, typically complicated by deep bacterial infections requiring prolonged systemic antibiotics. HYPOTHESIS/
objectivesThis split-body study, where dogs acted as their own control, evaluated whether the adjunctive use of fluorescent light energy (FLE) could shorten the time to clinical resolution of CIF and minimise systemic antimicrobial use. ANIMALS: Thirty-five client-owned dogs with signs of interdigital furunculosis in at least two paws. MATERIALS AND
methodsThis prospective, single-blinded, randomised, split-body multicentre clinical trial treated dogs with systemic antibiotics based on bacterial culture and sensitivity. One paw per dog was randomly selected using a coin-toss method for weekly FLE application, while the other paw served as a control. Dogs were scored every 2 weeks over 56 days on two parameters: a global lesion score (including haemorrhagic vesicles, fistulae with draining tracts, crusts and ulcers) and neutrophils engulfing bacteria score (NES, 0-4). Time to clinical resolution and lesion scores were assessed and compared between groups.
resultsAt Day (D)28 and D56, the FLE group showed significantly more healed paws (50% and 88%, p = 0.021) compared to the control (17% and 54%, p = 0.008). The median time to clinical resolution was shorter for the FLE group (35 days) compared to the control group (56 days, p = 0.017). No difference in NES score was observed between groups. CONCLUSIONS AND CLINICAL RELEVANCE: This blinded, randomised, split-body clinical trial demonstrated that FLE is an effective adjunctive therapy for CIF. It reduces the time to clinical resolution and increases the resolution rate while minimising the need for antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.