Evidence map›Paper›PMID 40116175›Full record

ArticleActa physiologica (Oxford, England)2025

Hypoxia and ischemic stroke modify cerebrovascular tone by upregulating endothelial BK(Ca) channels-Lessons from rat, pig, mouse, and human.

Christian Staehr, Victoria Hinkley, Vladimir V Matchkov, Rajkumar Rajanathan, Line Mathilde B Hansen, Yvonne Eiby, Nathan Luque, Ian Wright, Stella T Bjorkman, Stephanie M Miller and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Vascular Mechanobiology: From Membrane to Nucleus.Advances in experimental medicine and biology · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Christian StaehrDepartment of Biomedicine, Health, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-5431-4409
Victoria HinkleyBiomedical Science, School of Health, University of the Sunshine Coast, Maroochydore, Queensland, Australia.ORCID https://orcid.org/0000-0003-3117-2676
Vladimir V MatchkovDepartment of Biomedicine, Health, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-3303-1095
Rajkumar RajanathanDepartment of Biomedicine, Health, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-5002-5244
Line Mathilde B HansenDepartment of Biomedicine, Health, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-2116-578X
Yvonne EibyUQ Centre for Clinical Research, School of Clinical Medicine, Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0003-0079-7796
Nathan LuqueBlacktown Clinical School, Faculty of Medicine, Western Sydney University, Blacktown, New South Wales, Australia.ORCID https://orcid.org/0000-0003-3392-566X
Ian WrightUQ Centre for Clinical Research, School of Clinical Medicine, Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0001-5337-0134
Stella T BjorkmanUQ Centre for Clinical Research, School of Clinical Medicine, Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0002-6545-3962
Stephanie M MillerUQ Centre for Clinical Research, School of Clinical Medicine, Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0002-5565-2001
Rohan S GrimleySunshine Coast University Hospital, Birtinya, Queensland, Australia.ORCID https://orcid.org/0000-0002-7006-6908
Andrew DettrickSunshine Coast University Hospital, Birtinya, Queensland, Australia.ORCID https://orcid.org/0000-0003-2403-6027
Kirat ChandUQ Centre for Clinical Research, School of Clinical Medicine, Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0001-7739-2098
Hong L NguyenDepartment of Pharmacology, School of Biomedical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-1046-4733
Nicole M JonesDepartment of Pharmacology, School of Biomedical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0001-6738-6022
Tim V MurphyDepartment of Physiology, School of Biomedical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-0110-9548
Shaun L SandowBiomedical Science, School of Health, University of the Sunshine Coast, Maroochydore, Queensland, Australia.ORCID https://orcid.org/0000-0002-0753-2742

Funding

Augustinus Fonden #21-2471BRAIN FoundationDagmar Marshalls FondDanish Cardiovascular Academy PDC5-2024004-DCADanmarks Frie ForskningsfondGerhard Brøndsteds RejselegatHelga og Peter Kornings Fond 472123-006 #55Independent Research Fund Denmark 8020-00084BKnud Højgaards FondLundbeck Foundation R344-2020-952Lundbeck Foundation R412-2022-449Novo Nordisk Foundation NNF20SA0067242Riisfort FondenUniversity of the Sunshine Coast SPARK
6 · The paper itself

Abstract

aimIn animal models and human cerebral arteries, the changes in endothelial cell (EC)-large conductance calcium-activated potassium channel (BK

methodsImmunohistochemistry analyzed BK

resultsIn rat, pig, and human cerebral vessels, EC-BK

conclusionsIn post-hypoxia/stroke, but not in normoxia, EC-BK

Indexed as

Cerebrovascular CirculationEndothelial CellsEndothelium, VascularHypoxiaIschemic StrokeLarge-Conductance Calcium-Activated Potassium ChannelsAnimalsHumansMaleMiceMice, Inbred C57BLMiddle Cerebral ArteryRatsRats, Sprague-DawleySwineTRPV Cation ChannelsLarge-Conductance Calcium-Activated Potassium ChannelsTRPV Cation ChannelsBKCablood flowendotheliumhypoxiaion channelstroke

Identifiers

PMID40116175
PMCPMC11926774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.