SynthesisClinical oral implants research2025
Premature Bone Resorption in Vertical Ridge Augmentation: A Systematic Review and Network Meta-Analysis of Randomised Clinical Trials.
Synthesis in Clinical oral implants research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Trial
- Tenting screw (tent pole) technique in vertical and horizontal alveolar ridge augmentations: a systematic review and meta-analysis.Maxillofacial plastic and reconstructive surgery · 2026Review
- Vertical and Horizontal Ridge Augmentation with Titanium-Reinforced Dense PTFE and Reinforced PTFE Mesh: A Prospective Comparative Case Series.Journal of functional biomaterials · 2026Article
- Review
- The eggshell membrane as a barrier membrane for guided bone regeneration.Regenerative medicine · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesTo systematically appraise the evidence on premature ridge resorption following various vertical ridge augmentation (VRA) techniques in healthy adult patients undergoing staged VRA procedures. The study aimed to identify VRA techniques resulting in the least premature bone resorption and to rank them using Bayesian Network Meta-Analysis (NMA). MATERIAL AND
methodsSearches were conducted in six databases to identify randomised clinical trials (RCT) comparing staged VRA techniques with a minimum of 3 months follow-up. Relative premature bone resorption (PBR%) overall (primary) and in sites with uneventful versus complicated healing and need for additional bone grafting (NAG) (secondary) were chosen as outcomes. The risk of bias and certainty in evidence were assessed using Cochrane RoB 2.0 and GRADE tools. Bayesian models estimated treatment effects and rankings.
resultsTen RCTs, involving 220 participants and 236 defects, were included. Nine RCTs reported mean PBR%, with a range from 6% to 44%, averaging 26%. Seven treatment groups were evaluated: onlay, onlay + barrier, inlay, guided bone regeneration, distraction osteogenesis (DO), tissue expansion + tunnelling (TET), and cortical tenting. Eight RCTs, involving 160 participants and 176 defects, contributed to the NMA. Compared to onlay, all groups had lower mean PBR%. Inlay had the highest probability of being ranked first (Pr = 0.55), followed by DO (Pr = 0.27) and TET (Pr = 0.15). Healing complications significantly increased PBR% (MD 10%, 95% CrI 4.4-15.7).
conclusionVRA techniques preserving the periosteum (inlay, DO, and TET) exhibit less PBR compared with other techniques. When techniques involve full flap elevation, clinicians should anticipate volume loss at re-entry and consider greater grafting volumes to offset PBR. PROTOCOL REGISTRATION: PROSPERO ID: CRD42023394396; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=394396.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.