Evidence map›Paper›PMID 40116049›Full record

ArticleJournal of veterinary pharmacology and therapeutics2025

Pharmacokinetics and Bioavailability of Single-Dose Intramuscular and Intravenous Administration of Thiafentanil in Goats (Capra hircus).

Judith T Christie, Mieghan Bruce, Silke Pfitzer, Liesel Laubscher, Jacobus P Raath, Michael Laurence, Tracy Kellermann, Andrew P Woodward

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In one paragraph

Article in Journal of veterinary pharmacology and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Judith T ChristieSchool of Veterinary Medicine, Harry Butler Institute, Murdoch University, Murdoch, Western Australia, Australia.ORCID https://orcid.org/0000-0002-8579-2646
Mieghan BruceSchool of Veterinary Medicine, Harry Butler Institute, Murdoch University, Murdoch, Western Australia, Australia.
Silke PfitzerDepartment of Nature Conservation, Tshwane University of Technology, Pretoria, South Africa.
Liesel LaubscherWildlife Pharmaceuticals, Rocky Drift, White River, South Africa.
Jacobus P RaathWildlife Pharmaceuticals, Rocky Drift, White River, South Africa.
Michael LaurenceSchool of Veterinary Medicine, Harry Butler Institute, Murdoch University, Murdoch, Western Australia, Australia.
Tracy KellermannDivision of Clinical Pharmacology, Department of Medicine, Stellenbosch University, Stellenbosch, South Africa.
Andrew P WoodwardPrecision One Health Initiative, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.

Funding

Murdoch UniversitySouth African Veterinary Association's Wildlife Group Research FundWildlife Pharmaceuticals
6 · The paper itself

Abstract

Thiafentanil is a popular opioid agonist used for wildlife chemical immobilisation. Its effects are quickly and completely reversed by the antagonist naltrexone. Successful wildlife immobilisations using thiafentanil have been documented in a variety of wildlife species globally. The aim of this study was to describe the single-dose intramuscular (IM) and intravenous (IV) pharmacokinetics of thiafentanil in goats at a dose of 90 μg/kg using a single cross-over study. The IM dose was administered in the left Vastus lateralis. Plasma samples were collected up to 120 min after thiafentanil administration from two female and eight male adult goats. Samples were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Pharmacokinetic parameters from one and two-compartment models were estimated via a Bayesian approach. The two-compartment model was preferred overall. The estimated bioavailability was 0.677 (90% Crl: 0.542-0.888), absorption rate constant (k

Indexed as

Analgesics, OpioidFentanylGoatsAnimalsArea Under CurveBiological AvailabilityCross-Over StudiesFemaleHalf-LifeInjections, IntramuscularInjections, IntravenousMaleA3080Analgesics, OpioidFentanylBayesian statisticschemical immobilisationopioid agonistpharmacokineticsthiafentanil

Identifiers

PMID40116049
PMCPMC12257260

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.