Evidence map›Paper›PMID 40115966›Full record

ArticleIBRO neuroscience reports2025

Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease.

François Cossais, Marie Christin Hörnke, Katja Schröder, Ralph Lucius, Martina Böttner, Jan-Hendrik Egberts, Florian Richter, Thilo Wedel

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In one paragraph

Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

François CossaisInstitute of Anatomy, Kiel University, Kiel, Germany.
Marie Christin HörnkeInstitute of Anatomy, Kiel University, Kiel, Germany.
Katja SchröderInstitute of Anatomy, Kiel University, Kiel, Germany.
Ralph LuciusInstitute of Anatomy, Kiel University, Kiel, Germany.
Martina BöttnerInstitute of Anatomy, Kiel University, Kiel, Germany.
Jan-Hendrik EgbertsGeneral, Thoracic, Transplantation and Pediatric Surgery, Kiel University, University Medical Center Schleswig-Holstein, Kiel, Germany.
Florian RichterGeneral, Thoracic, Transplantation and Pediatric Surgery, Kiel University, University Medical Center Schleswig-Holstein, Kiel, Germany.
Thilo WedelInstitute of Anatomy, Kiel University, Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Phosphorylated alpha-synuclein (P-aSyn) is a biomarker for Parkinson's disease (PD), with potential relevance in intestinal inflammatory disorders. Objectives: This study examines the distribution of P-aSyn in colonic tissues of patients with diverticular disease (DD) compared to age-matched controls. Methods: P-aSyn distribution was analyzed in colon samples of 45 patients with diverticulitis (D-itis), 12 with diverticulosis (D-osis), and 30 controls via immunohistochemistry. Results: P-aSyn immunoreactivity was found along enteric neurons of the myenteric and submucosal plexus in 93.1 % of participants, with similar distribution across D-itis, D-osis, and controls. Elevated reactivity appeared in 16.7 % of D-osis, 19.6 % of D-itis, and 30.0 % of controls. Conclusion: P-aSyn presence in colonic tissue did not significantly differ between DD patients and controls, suggesting that DD-related inflammation does not notably affect P-aSyn expression. Further research is warranted to explore aSyn roles within the enteric nervous system in intestinal inflammatory disorders and their relation with neurodegenerative diseases.

Indexed as

Alpha-synucleinDiverticular diseaseEnteric nervous systemIntestinal inflammationParkinson’s disease

Identifiers

PMID40115966
PMCPMC11923801

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.