ArticleJournal of gastrointestinal oncology2025
Identification of a pyroptosis-related gene prognostic signature in patients with hepatocellular carcinoma.
Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Itaconate-Related Gene Signatures as Prognostic Markers in Colon Cancer: Insights From Transcriptomic and Spatial Analysis.Human mutation · 2026Article
- Prognostic value of a simplified score based on routine parameters in patients with hepatocellular carcinoma treated with systemic therapies: a retrospective cohort study.Journal of gastrointestinal oncology · 2025Article
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Authors and funding
9 authors.
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Abstract
Background: Pyroptosis has been recently identified as a hallmark of cancer biology; however, the potential of pyroptosis-related genes (PRGs) as prognostic markers has not been fully elucidated in hepatocellular carcinoma (HCC). The aim of this study was to develop a PRG-associated risk signature for prediction prognosis in patients with HCC. Methods: We identified 35 PRGs from the published literature, and pyroptosis subtypes were identified through bioinformatics methods. The risk score model was established by applying least absolute shrinkage and selection operator (LASSO) Cox regression method in The Cancer Genome Atlas (TCGA) cohort and validated in International Cancer Genome Consortium (ICGC) datasets. Additionally, immune infiltration, enriched pathways, and genomic alterations were compared between the high- and low-risk score subgroups. Finally, a nomogram containing the pyroptosis risk score and other prognosis-related clinical factors was developed for predicting the overall survival of patients with HCC. Results: Based on the expression profile of PRGs, we determined two pyroptosis-related subtypes (cluster A and cluster B) of HCC associated with different immune characteristics and significantly different prognoses. The risk score model showed that upregulation of Conclusions: We developed and verified a prognostic risk model based on PRGs for patients with HCC, which may provide a robust tool for predicting outcomes in this setting.
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