Evidence map›Paper›PMID 40115746›Full record

ArticleBiological psychiatry global open science2025

A Hidden Mark of a Troubled Past: Neuroimaging and Transcriptomic Analyses Reveal Interactive Effects of Maternal Immune Activation and Adolescent THC Exposure Suggestive of Increased Neuropsychiatric Risk.

Mario Moreno-Fernández, Víctor Luján, Shishir Baliyan, Celia Poza, Roberto Capellán, Natalia de Las Heras-Martínez, Miguel Ángel Morcillo, Marta Oteo, Emilio Ambrosio, Marcos Ucha and 1 more

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In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mario Moreno-FernándezDepartment of Psychobiology, Faculty of Psychology, National University of Distance Education (UNED), Madrid, Spain.
Víctor LujánDepartment of Psychobiology, Faculty of Psychology, National University of Distance Education (UNED), Madrid, Spain.
Shishir BaliyanDepartment of Psychobiology, Faculty of Psychology, National University of Distance Education (UNED), Madrid, Spain.
Celia PozaDepartment of Psychobiology, Faculty of Psychology, National University of Distance Education (UNED), Madrid, Spain.
Roberto CapellánDepartment of Psychobiology, Faculty of Psychology, National University of Distance Education (UNED), Madrid, Spain.
Natalia de Las Heras-MartínezDepartment of Psychobiology, Faculty of Psychology, National University of Distance Education (UNED), Madrid, Spain.
Miguel Ángel MorcilloMedical Application of Ionising Radiations Unit, Centre for Energy, Environmental and Technological Research (CIEMAT), Madrid, Spain.
Marta OteoMedical Application of Ionising Radiations Unit, Centre for Energy, Environmental and Technological Research (CIEMAT), Madrid, Spain.
Emilio AmbrosioDepartment of Psychobiology, Faculty of Psychology, National University of Distance Education (UNED), Madrid, Spain.
Marcos UchaDepartment of Psychobiology, Faculty of Psychology, National University of Distance Education (UNED), Madrid, Spain.
Alejandro Higuera-MatasDepartment of Psychobiology, Faculty of Psychology, National University of Distance Education (UNED), Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Maternal exposure to infections during gestation has been shown to predispose individuals to neuropsychiatric disorders. Additionally, clinical data suggest that cannabis use may trigger the onset of schizophrenia in vulnerable individuals. However, the direction of causality remains unclear. Methods: To elucidate this issue, we utilized a rat model of maternal immune activation combined with exposure to increasing doses of Δ Results: While adolescent Δ Conclusions: These results suggest that the combination of these 2 vulnerability factors leaves a lasting mark on the body, potentially predisposing individuals to neuropsychiatric disorders even before behavioral alterations manifest.

Indexed as

AdolescenceCannabinoidsMaternal immune activationOrbitofrontal cortexPETTranscriptome

Identifiers

PMID40115746
PMCPMC11925510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.