Evidence map›Paper›PMID 40115708›Full record

ArticleCureus2025

Medication-Related Osteonecrosis Successfully Treated With Hyperbaric Oxygen Therapy and Conservative Treatment: A Case Report.

Tougo Tanabe, Taku Kimura, Ken-Ichiro Sakata, Noritaka Ohga, Aya Yanagawa-Matsuda, Yoshinori Kobori

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tougo TanabeDepartment of Oral Diagnosis and Medicine, Hokkaido University, Sapporo, JPN.
Taku KimuraDepartment of Oral Diagnosis and Medicine, Hokkaido University, Sapporo, JPN.
Ken-Ichiro SakataDepartment of Oral Diagnosis and Medicine, Hokkaido University, Sapporo, JPN.
Noritaka OhgaDepartment of Oral Diagnosis and Medicine, Hokkaido University, Sapporo, JPN.
Aya Yanagawa-MatsudaDepartment of Vascular Biology and Molecular Pathology, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo, JPN.
Yoshinori KoboriDepartment of Oral Surgery, Azabu Triology Hospital, Sapporo, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medication-related osteonecrosis of the jaws (MRONJ) is a major side effect of the antiresorptive drugs used in treating patients with osteoporosis and cancer. MRONJ appears as prolonged inflammation affecting the maxilla or mandible, with necrotic bone exposure and intraoral and extraoral fistulas. According to previous studies, surgery for this condition is highly beneficial. However, extensive surgical treatment generally overburdens patients with MRONJ, who often already suffer from other diseases such as cancer; therefore, further consideration must be given to their overall condition. Herein, we present the case of an elderly patient with extensive MRONJ who was successfully treated with hyperbaric oxygen therapy and conservative treatment.

Indexed as

conservative treatmentdenosumabhyperbaric oxygen therapy (hbo therapy)medical collaborationmedication-related osteonecrosis of the jaws (mronj)

Identifiers

PMID40115708
PMCPMC11924813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.