ArticleTH open : companion journal to thrombosis and haemostasis2025
Problem Solved? An Individual Ratio between Point-of-Care and Venous International Normalized Ratio Values in Two Patients with Antiphospholipid Syndrome: Two Case Reports.
Article in TH open : companion journal to thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by thromboembolic and obstetric complications in the presence of persistent antiphospholipid antibodies (aPL). Treatment aims to prevent recurrent thrombosis, primarily using anticoagulation therapy with vitamin K antagonists (VKA). Monitoring of VKA therapy relies on the International Normalized Ratio (INR), which can be assessed using point-of-care testing (POCT). However, in a subset of APS patients with a high-risk aPL profile, the POCT-INR is falsely elevated, which might lead to underdosing of VKA and subsequent high risk of recurrent thrombosis. This case report describes two female patients with triple-positive thrombotic APS receiving VKA therapy. Both patients underwent biweekly paired INR measurements via POCT-INR and venous INR methods. Despite significant discrepancies, a strong individual linear correlation was observed:
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