Evidence map›Paper›PMID 40115448›Full record

ArticleTranslational pediatrics2025

Antimicrobial photodynamic therapy and deproteinization in teeth with molar incisor hypomineralization: a case series.

Amanda Rafaelly Honório Mandetta, Carolina Carvalho Bortoletto, Ana Paula Taboada Sobral, Thais Gimenez, Caroline Diniz Pagani Vieira Ribeiro, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Raquel Agnelli Mesquita-Ferrari, Renato Araujo Prates, Alessandro Melo Deana and 5 more

Abstract readCase Reports
In one paragraph

Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Amanda Rafaelly Honório MandettaBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.
Carolina Carvalho BortolettoBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.
Ana Paula Taboada SobralSchool of Dentistry, Universidade Metropolitana de Santos, Santos, Brazil.
Thais GimenezSchool of Dentistry, Universidade de São Paulo, São Paulo, Brazil.
Caroline Diniz Pagani Vieira RibeiroBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.
Lara Jansiski MottaBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.
Anna Carolina Ratto Tempestini HorlianaBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.
Raquel Agnelli Mesquita-FerrariBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.
Renato Araujo PratesBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.
Alessandro Melo DeanaBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.
Cinthya Cosme Gutierrez DuranBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.
Rita de Cássia Loiola CordeiroResearch of Department of Pediatric Dentistry, São Paulo State University, Araraquara School of Dentistry, UNESP-Araraquara, São Paulo, Brazil.
Kristianne Porta Santos FernandesBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.
Lourdes Aparecida Martins Dos Santos-PintoResearch of Department of Pediatric Dentistry, São Paulo State University, Araraquara School of Dentistry, UNESP-Araraquara, São Paulo, Brazil.
Sandra Kalil BussadoriBiophotonics Medicine Postgraduate Program, Universidade Nove de Julho, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Molar incisor hypomineralization (MIH) is a complex developmental enamel defect influenced by various factors, including genetic predisposition. This condition primarily affects the first permanent molars and, in some instances, the permanent incisors. In this case series, we examined the clinical effects of antimicrobial photodynamic therapy (aPDT) and deproteinization with Papacárie on teeth with MIH and carious lesions, focusing on decontamination, hypersensitivity control, and restoration longevity with the use of minimally invasive techniques. Case Description: Seven permanent first molars from children aged 7 to 10 years, with carious dentin lesions and post-eruptive fractures, which required restorative clinical treatment, were selected. Selective chemical-mechanical removal of carious tissue and deproteinization were performed using Papacárie Conclusions: aPDT proved to be promising treatment for decontamination and hypersensitivity control in molars with hypomineralization and dentinal caries. Moreover, deproteinization with Papacárie offers a promising, minimally invasive approach for enhancing restoration longevity.

Indexed as

case seriesdental atraumatic restorative treatmenthypersensitivityMolar incisor hypomineralization (MIH)photochemotherapy

Identifiers

PMID40115448
PMCPMC11921251

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.