Evidence map›Paper›PMID 40115382›Full record

ArticleFrontiers in neurology2025

Healthy dietary intake diminishes the effect of cerebral small vessel disease on cognitive performance in older adults.

Christopher E Bauer, Valentinos Zachariou, Colleen Pappas, Pauline Maillard, Charles DeCarli, Arvind Caprihan, Brian T Gold

Abstract read
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher E BauerDepartments of Neuroscience, University of Kentucky, Lexington, KY, United States.
Valentinos ZachariouBehavioral Science, University of Kentucky, Lexington, KY, United States.
Colleen PappasDepartments of Neuroscience, University of Kentucky, Lexington, KY, United States.
Pauline MaillardDepartments of Neurology, University of California, Davis, Davis, CA, United States.
Charles DeCarliDepartments of Neurology, University of California, Davis, Davis, CA, United States.
Arvind CaprihanThe Mind Research Network, Albuquerque, NM, United States.
Brian T GoldDepartments of Neuroscience, University of Kentucky, Lexington, KY, United States.

Funding

UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI WILCOCK, DONNA M · 2006 to 2020
$23.3M
Identifying Associations between Brain Iron, Neurocognitive Networks and Protective FactorsR01AG068055 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY · 2021 to 2025
$2.8M
Contributions of Alzheimer's Pathology and Cerebrovascular Factors to Cognitive AgingR01AG055449 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY · 2017 to 2021
$2.3M
Reduced BBB Water Exchange as a Preclinical Biomarker of Small Vessel DiseaseRF1NS122028 · NINDS · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY, WANG, DANNY JJ · 2022 to 2022
$2.0M
Essential Siemens Prisma Fit Upgrade for the University of Kentucky 3T Research ScannerS10OD023573 · OD · UNIVERSITY OF KENTUCKY · PI SMITH, CHARLES DENNIS · 2017 to 2017
$813k
NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG055449NIA NIH HHS R01 AG068055NIH HHS S10 OD023573NINDS NIH HHS RF1 NS122028
6 · The paper itself

Abstract

Introduction: We evaluated whether regular dietary intake of nutrients commonly found in fish, unsaturated oils, and nuts would moderate the associations between neuroimaging biomarkers of cerebral small vessel disease (cSVD) and cognitive function in older adults. Methods: Dietary information, Montreal Cognitive Assessment (MoCA) scores, and magnetic resonance imaging (MRI) scans were collected from 71 older adults without dementia (60-86 years). MRI biomarkers of cSVD were calculated for each participant. Multivariate linear regression models were computed using dietary intake as the moderating variable. Covariates included age, sex, and estimated intracranial volume. Results: Dietary intake moderated the association between several cSVD biomarkers and MoCA scores such that the expected negative association between cSVD biomarkers and cognition was seen at low levels of healthy dietary intake, but not at medium or high levels. A dietary intake by age moderation was not observed. Discussion: Our findings indicate that healthy dietary intake may confer cognitive reserve against cSVD in older adults.

Indexed as

cerebral small vessel diseasecerebrovascular diseasecognitive reservefree waterMediterranean dietnutritionpeak width of skeletonized mean diffusivityvascular contributions to cognitive impairment and dementia

Identifiers

PMID40115382
PMCPMC11925079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.