Evidence map›Paper›PMID 40115377›Full record

ArticleGynecologic oncology reports2025

Second-line antibody-drug conjugates for the treatment of metastatic human papillomavirus-independent gastric-type adenocarcinoma of cervix: The Singapore experience.

Daniel Jia Ming Ang, Ke Xin Bok, Shing Lih Wong, Yihan Li, Adele Wong, Yen Ching Yeo, Junjie Wang, Ieera Madan Aggarwal, Jack Junjie Chan

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel Jia Ming AngDivision of Medical Oncology, National Cancer Centre Singapore, Singapore.
Ke Xin BokDivision of Medical Oncology, National Cancer Centre Singapore, Singapore.
Shing Lih WongDepartment of Anatomical Pathology, Singapore General Hospital, Singapore.
Yihan LiDepartment of Anatomical Pathology, Singapore General Hospital, Singapore.
Adele WongDepartment of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.
Yen Ching YeoDepartment of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.
Junjie WangDepartment of Gynaecological Oncology, KK Women's and Children's Hospital, Singapore.
Ieera Madan AggarwalDepartment of Gynaecological Oncology, KK Women's and Children's Hospital, Singapore.
Jack Junjie ChanDivision of Medical Oncology, National Cancer Centre Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV)-independent gastric-type adenocarcinoma (GAS) is a rare, aggressive, chemoresistant histological subtype of cervical cancer which occurs more commonly in patients of Asian descent. Patients with GAS tend to have poorer overall outcomes compared to HPV-associated adenocarcinomas of the cervix. The antibody-drug conjugates (ADCs) tisotumab vedotin-tftv (TV) and trastuzumab deruxtecan (T-DXd) are approved for use in previously treated metastatic cervical cancer, the latter in HER2-expressing tumors. There is paucity of data regarding the efficacy and safety of TV and T-DXd in the management of metastatic GAS. We report outcomes of four patients with metastatic GAS who were treated with these ADCs in the second-line setting in Singapore.

Indexed as

Antibody-drug conjugatesCervical cancerMucinous carcinoma

Identifiers

PMID40115377
PMCPMC11925155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.