Evidence map›Paper›PMID 40115136›Full record

ArticleInternational journal of preventive medicine2025

The Heart Tissue Molecular Response to Resistance Training in Comparison to Irisin Injection: A Focus on VEGF Gene/Protein Expression and Correlations with Serum Irisin Levels.

Mohammad Hassan Olamazadeh, Fahimeh Esfarjani, Sayed Mohammad Marandi, Saeed Zamani, Fahimeh Zamani Rarani, Mohammadreza Sharifi

Abstract read
In one paragraph

Article in International journal of preventive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad Hassan OlamazadehDepartment of Exercise Physiology, Faculty of Sport Science, University of Isfahan, Isfahan, Iran.
Fahimeh EsfarjaniDepartment of Exercise Physiology, Faculty of Sport Science, University of Isfahan, Isfahan, Iran.
Sayed Mohammad MarandiDepartment of Exercise Physiology, Faculty of Sport Science, University of Isfahan, Isfahan, Iran.
Saeed ZamaniDepartment of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Fahimeh Zamani RaraniDepartment of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammadreza SharifiDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Angiogenesis is crucial in the recovery and maintenance of heart function. Irisin may mediate the cardiac health-promoting impact of exercise training. The aim of this study was to comparatively assess VEGF gene/protein expression in the heart tissue and correlations with serum irisin levels following resistance training, in comparison to exogenous irisin injection. Methods: Twenty-one Results: The expression of the VEGF gene and protein, as well as serum Irisin levels, increased in all experimental mice compared to the control group ( Conclusions: There appears to be an interaction between resistance exercise and cardiac angiogenesis factors, mediated by irisin. So, irisin could be considered in cardiovascular health interventions, aiming to target specific molecules or pathways.

Indexed as

AngiogenesisheartIrisinresistance trainingVEGF

Identifiers

PMID40115136
PMCPMC11925359

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.