Evidence map›Paper›PMID 40115130›Full record

ArticleFrontiers in toxicology2025

Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice.

Victor J Johnson, Cynthia V Rider, Michael I Luster, Cynthia J Willson, Shawn Harris, Billie Stiffler, James Blake, Esra Mutlu, Veronica Godfrey, Brian Burback and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Victor J JohnsonBurleson Research Technologies, Inc., Morrisville, NC, United States.
Cynthia V RiderDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
Michael I LusterBurleson Research Technologies, Inc., Morrisville, NC, United States.
Cynthia J WillsonIntegrated Laboratory Systems, LLC, An Inotiv Company, Morrisville, NC, United States.
Shawn HarrisDLH, LLC, Bethesda, MD, United States.
Billie StifflerBattelle, Columbus, OH, United States.
James BlakeRTI International, Research Triangle Park, NC, United States.
Esra MutluDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
Veronica GodfreyDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
Brian BurbackBattelle, Columbus, OH, United States.
Reshan FernandoRTI International, Research Triangle Park, NC, United States.
Suramya WaidyanathaDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
Gary R BurlesonBurleson Research Technologies, Inc., Morrisville, NC, United States.
Dori R GermolecDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.

Funding

Combined Exposures and Mixtures Research ProgramZIAES103373 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, CYNTHIA · 2022 to 2025
$5.6M
Chemistry Services Supporting the Division of Translational ToxicologyZICES103391 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WAIDYANATHA, SURAMYA · 2023 to 2025
$3.1M
Intramural NIH HHS ZIA ES103373Intramural NIH HHS ZIC ES103391NIH HHS HHSN273201400017CNIH HHS HHSN273201400022CNIH HHS HHSN273201400027C
6 · The paper itself

Abstract

Introduction: The ability of polycyclic aromatic compounds (PACs), most notably benzo( Methods: In the current study, adult B6C3F1/N female mice were treated daily for 28 consecutive days by oral administration of B( Results: Benzo( Conclusion: Suppression of the TDAR to SRBC immunization was the most sensitive immune endpoint being 33 times more sensitive than changes in liver weight, a commonly used outcome for risk assessment for PACs. Benzo(

Indexed as

benzo(a)pyreneimmunosuppressionimmunotoxicityphenanthrenepolycyclic aromatic compounds (pac)polycyclic aromatic hydrocarbons (PAH)pyrene

Identifiers

PMID40115130
PMCPMC11922959

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.