ReviewAnnals of translational medicine2025
Efficacy of statins in tissue healing following tooth extraction: a systematic review of animal studies.
Review in Annals of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre-Implant Bone Regeneration: A Systematic Review and Meta-Analysis.Clinical and experimental dental research · 2026Pooled it
- Quality of life of patients receiving short dental implants in microvascular free flaps: a five year prospective study.Scientific reports · 2025Article
- The Effect of Local Simvastatin on Alveolar Bone Regeneration, Pain, and Swelling After Tooth Extraction: a Systematic Review.Journal of oral & maxillofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Statins, with their unique ability to stimulate bone formation and soft tissue healing, hold the potential to revolutionize dental care. The present study aims to delve into the profound effects of statins on bone and soft tissue healing in dental extraction sockets, offering a promising future for dental professionals and patients alike. Methods: This systematic review aimed to understand the role of stains in tissue healing following dental extraction. This study was registered in the International Prospective Register of Ongoing Systematic Reviews (PROSPERO; CRD42022299247). A comprehensive electronic database search yielded 412 manuscripts. After a rigorous screening process, nine manuscripts met the eligibility criteria. The study sample consisted of 403 animals, with eight studies utilizing rat animal models and one conducted on mongrel dogs. Results: Overall, the application of statin drugs holds promise for improving tissue healing outcomes following tooth extraction. The primary outcome variables across all studies were residual ridge height and width, messenger ribonucleic acid (mRNA) expression of transforming growth factor-beta 1 (TGF-β1), bone morphogenetic protein-2 (BMP-2), and vascular endothelial growth factor (VEGF), bone and gingival healing, inflammatory response, and bone turnover (BT), bone formation in tooth extraction socket, and osteogenic healing in a tooth extraction socket. Conclusions: The findings of this study underscore the significant potential of statin drugs to enhance tissue healing outcomes following tooth extraction. This discovery opens new and exciting possibilities for improving dentistry patient care, potentially transforming how we approach post-extraction healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.