Evidence map›Paper›PMID 40114985›Full record

ArticleBJA open2025

Premedication with intranasal dexmedetomidine in patients undergoing total knee arthroplasty under spinal anaesthesia (TKADEX)-a prospective, double-blinded, randomised controlled trial.

Suvi-Maria Tiainen, Heta Heinonen, Atte Koskinen, Sanna Mäkelä, Ruut Laitio, Eliisa Löyttyniemi, Keijo Mäkelä, Teijo I Saari, Panu Uusalo

Registry-linked trialAbstract read
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In one paragraph

Article in BJA open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04859283 (Premedication with Intranasal Dexmedetomidine in Sedation of Patients Undergoing Total Knee Arthroplasty), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04859283 phase4completednot on this map

Premedication with Intranasal Dexmedetomidine in Sedation of Patients Undergoing Total Knee Arthroplasty

TypeinterventionalSponsorTurku University HospitalRan2022 to 2025Enrolled100ConditionsKnee Osteoarthritis, Pain, PostoperativeArmsDexmedetomidine, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suvi-Maria TiainenDepartment of Anaesthesiology and Intensive Care, University of Turku, Turku, Finland.
Heta HeinonenMedical Faculty, University of Turku, Turku, Finland.
Atte KoskinenDepartment of Anaesthesiology and Intensive Care, University of Turku, Turku, Finland.
Sanna MäkeläDepartment of Anaesthesiology and Intensive Care, University of Turku, Turku, Finland.
Ruut LaitioDepartment of Anaesthesiology and Intensive Care, University of Turku, Turku, Finland.
Eliisa LöyttyniemiDepartment of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.
Keijo MäkeläDepartment of Orthopaedics and Traumatology, Turku University Hospital, and University of Turku, Turku, Finland.
Teijo I SaariDepartment of Anaesthesiology and Intensive Care, University of Turku, Turku, Finland.
Panu UusaloDepartment of Anaesthesiology and Intensive Care, University of Turku, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies have shown that perioperative use of adjuvants, such as the alpha-2 agonist dexmedetomidine, may reduce postoperative pain and opioid requirements. However, information about optimal dosing is lacking. We investigated if premedication with intranasal dexmedetomidine compared with placebo reduces postoperative pain in patients undergoing total knee arthroplasty under spinal anaesthesia. Methods: This single-centre, double-blind, two-arm study compared premedication with intranasal dexmedetomidine (single 1 μg kg Results: Patients in the dexmedetomidine group had lower numerical rating scale scores [median (interquartile range) 2.0 (0.0-3.0)] at 3 h when compared with the control group [3.0 (2.0-4.0)] ( Conclusions: Our results indicate that intranasal dexmedetomidine may reduce postoperative pain and the requirement for additional sedation and increase short-term patient satisfaction in patients undergoing total knee arthroplasty. Clinical trial registration: ClinicalTrials.gov (NCT04859283).

Indexed as

dexmedetomidineintranasal deliverymultimodal analgesianonopioid analgesicspatient satisfactionpremedication

Identifiers

PMID40114985
PMCPMC11923756

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.