Evidence map›Paper›PMID 40114975›Full record

ArticleOpen forum infectious diseases2025

Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya.

Louise O Downs, Dorcas Okanda, Oscar Chirro, Mwanakombo Zaharani, Benson Safari, Nadia Aliyan, Monique I Andersson, Yasuhito Tanaka, Anthony O Etyang, Yusuke Shimakawa and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Louise O DownsNuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-6088-4704
Dorcas OkandaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Oscar ChirroKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-1799-8503
Mwanakombo ZaharaniKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Benson SafariKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Nadia AliyanKilifi County Hospital, Kilifi, Kenya.
Monique I AnderssonRadcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0003-0619-1074
Yasuhito TanakaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID https://orcid.org/0000-0002-2473-6966
Anthony O EtyangNuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0003-1267-6422
Yusuke ShimakawaPasteur International Unit at Kumamoto University, National Center for Global Health and Medicine, Kumamoto, Japan.ORCID https://orcid.org/0000-0002-4198-4785
George GithinjiKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0001-9640-7371
Philippa C MatthewsThe Francis Crick Institute, London, UK.ORCID https://orcid.org/0000-0002-4036-4269

Funding

Wellcome Trust CC2223
6 · The paper itself

Abstract

We undertook a point-of-care test for hepatitis B core-related antigen in adults with hepatitis B virus in Kilifi, Kenya. A positive test identified all individuals with a hepatitis B viral load >200 000 IU/mL and who were hepatitis B e antigen positive. It also correlated with a higher alanine aminotransferase (ALT) level (

Indexed as

HBVhepatitis B core-related antigenliver diseasepoint-of-care diagnosticstreatment

Identifiers

PMID40114975
PMCPMC11923541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.