Evidence map›Paper›PMID 40114837›Full record

ArticleTranslational andrology and urology2025

The fate of the urethra after artificial urinary sphincter cuff erosion: a review of 98 patients.

Jeffrey C Loh-Doyle, Jeffery S Lin, David A Ginsberg, Emily Markarian, Ryan Davis, Leo R Doumanian, Stuart D Boyd

Abstract read
In one paragraph

Article in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jeffrey C Loh-DoyleInstitute of Urology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Jeffery S LinKaiser Permanente, Los Angeles, CA, USA.
David A GinsbergInstitute of Urology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Emily MarkarianInstitute of Urology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Ryan DavisInstitute of Urology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Leo R DoumanianInstitute of Urology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Stuart D BoydInstitute of Urology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cuff erosion following artificial urinary sphincter (AUS) implantation, can have devastating downstream sequelae. As there is a paucity of literature regarding outcomes following AUS removal due to erosion, we aim to report rates of urinary fistulae (UF) and urethral stricture (US) complications after AUS removal in patients presenting with AUS cuff erosion. Methods: A retrospective chart review was performed on all patients who underwent AUS explant due to erosion from July 2009 to December 2020 at University of Southern California/Norris Comprehensive Cancer Center. All patients were managed with a standardized approach that involves prompt device explantation, suture urethrorraphy, and continual urethral catheter drainage. Patient demographic data, hypothesized cause of erosion, and post-operative outcomes were collated. Results: A total of 98 patients underwent AUS removal due to erosion. No intraoperative complications occurred during AUS explantation. The median age at AUS erosion was 79.4 years old [interquartile range (IQR), 72.7-83.1 years] with 45 (45.9%) of age 80 or greater. The median follow-up after AUS removal was 19.8 months (IQR, 7.0-49.2 months). Of these patients, 86 (87.8%) had a "fragile" urethra (history of pelvic radiotherapy, urethroplasty, or prior AUS failure or erosion) with 28 (28.6%) having two or more risk factors prior to AUS erosion at our institution. Fifty-three (54.1%) patients had history of pelvic radiation, 14 (14.3%) had a previous erosion, 6 (6.1%) had previous cuff relocation unrelated to erosion, and 6 (6.1%) had dual cuffs, 18 (18.4%) had a previous history of a posterior transecting urethroplasty, and 2 (2.0%) had a previous anterior urethroplasty. Of the 98 patients, 6 (6.1%) developed a Conclusions: In a contemporary cohort of patients presenting with AUS cuff erosion, rates of UCF and US are low. Due to the increassed risk of these complications after prior erosions, strategies to prevent initial erosion events should be further explored.

Indexed as

artificial urinary sphincter (AUS)urethra erosionurethra strictureUrinary fistulae (UF)urinary incontinence

Identifiers

PMID40114837
PMCPMC11921313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.