Evidence map›Paper›PMID 40114783›Full record

ArticleBrain communications2025

Lana M Chahine, David-Erick Lafontant, Seung Ho Choi, Hirotaka Iwaki, Cornelis Blauwendraat, Andrew B Singleton, Michael C Brumm, Roy N Alcalay, Kalpana Merchant, Kelly Nicole Holohan Nudelman and 16 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Ex Vivo LRRK2 Activation in Asian G2385R and R1628P Variant Carriers and Idiopathic Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Integrated Biofluid Proteomics Identified Dynamic Functional Biomarkers ofmedRxiv : the preprint server for health sciences · 2025
    Article
  13. Review
  14. Article
  15. Affective phenotypes in heterozygousFrontiers in genetics · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Lana M ChahineDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
David-Erick LafontantDepartment of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 55848, USA.
Seung Ho ChoiDepartment of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 55848, USA.
Hirotaka IwakiDataTecnica LLC, Washington, DC 20037, USA.
Cornelis BlauwendraatCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-9358-8111
Andrew B SingletonCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.
Michael C BrummDepartment of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 55848, USA.
Roy N AlcalayTel Aviv Sourasky Medical Center, 64239 Tel-Aviv, Israel.
Kalpana MerchantDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Kelly Nicole Holohan NudelmanDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202, USA.
Alain DagherMontreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4.ORCID https://orcid.org/0000-0002-0945-5779
Andrew VoMontreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4.
Qin TaoMontreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4.
Charles S VenutoDepartment of Neurology, Center for Health and Technology, University of Rochester Medical Center, Rochester, NY 14642,USA.
Karl KieburtzDepartment of Neurology, Center for Health and Technology, University of Rochester Medical Center, Rochester, NY 14642,USA.
Kathleen L PostonDepartment of Neurology, Stanford University School of Medicine, Palo Alto, 94304 CA, USA.
Susan BressmanDepartment of Neurology, Icahn School of Medicine, Mount Sinai Beth Israel, New York City, NY 10029, USA.
Paulina Gonzalez-LatapiDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Brian AvantsInvicro, LLC, Needham, MA 02494, USA.
Christopher CoffeyDepartment of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 55848, USA.
Danna JenningsDenali Therapeutics Inc., South San Francisco, CA 94080, USA.
Eduardo TolosaParkinson's Disease & Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Andrew SiderowfDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ken MarekInstitute for Neurodegenerative Disorders, New Haven, CT 06510, USA.
Tatyana SimuniDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Parkinson’s Progression Markers Initiative

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among

Indexed as

alpha-synucleinLRRK2 geneParkinson’s disease

Identifiers

PMID40114783
PMCPMC11925012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.