Evidence map›Paper›PMID 40114585›Full record

Observational studyAnnals of medicine2025

Long-term prognostic value of thyroid hormone levels in chronic critical illness patients.

Zhaoxiang Li, Liang Wang, Jianling Shi, Weiying Han, Chengrui Zhu, Tingrui Zhang, Xiaochun Ma, Yingjian Liang

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhaoxiang LiDepartment of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China.
Liang WangDepartment of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China.
Jianling ShiDepartment of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China.
Weiying HanDepartment of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China.
Chengrui ZhuDepartment of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China.
Tingrui ZhangDepartment of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China.
Xiaochun MaDepartment of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-1714-9800
Yingjian LiangDepartment of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic critical illness (CCI) can manifest as dysfunction of thyroid hormones. This study aimed to investigate the predictive value of the nonthyroidal illness syndrome (NTIS) for the prognosis of CCI patients, establish a predictive model for the prognosis of CCI patients, and evaluate the efficacy of the model to provide a theoretical basis for clinical intervention.

methodsThis was a prospective observational study in which patients ≥18 years old who met the CCI criteria were enrolled. The primary outcome of the study was 90-day mortality after intensive care unit (ICU) admission. A nomogram was constructed to predict the prognosis of CCI patients, and the model was evaluated via the concordance index, calibration curve and decision curve analysis.

resultsA total of 545 patients were included, and NTIS patients accounted for 65.3% of the patients. CCI patients with NTIS had more ventilator days and higher 90-day mortality. Lower free triiodothyronine (FT3) levels (<1.19 pmol/L) or reduced free thyroxine (FT

conclusionsDecreased serum FT3 and FT4 concentrations in patients with CCI at admission to the ICU on day 10 are associated with 90-day mortality. Early detection of serum FT3 and FT4 levels could help clinicians target CCI patients at high risk of clinical deterioration.

Indexed as

Critical IllnessEuthyroid Sick SyndromesThyroid HormonesThyroxineTriiodothyronineAdultAgedChronic DiseaseFemaleHumansIntensive Care UnitsMaleMiddle AgedNomogramsOrgan Dysfunction ScoresPredictive Value of TestsThyroid HormonesThyroxineTriiodothyroninechronic critical illnessNonthyroidal illness syndromepredictive modelprognosistriiodothyronine

Identifiers

PMID40114585
PMCPMC11934158

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.