Evidence map›Paper›PMID 40114551›Full record

ArticleJournal of gynecologic oncology2025

A decade data of HPV genotypes in metropolitan regions of Indonesia: paving the way for a national cervical cancer elimination strategy.

Tofan Widya Utami, Laila Nuranna, Syifa Ainun Rahman, Raysa Irzami, Andi Utama, Gatot Purwoto, Eva Suarthana

Abstract read
In one paragraph

Article in Journal of gynecologic oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tofan Widya UtamiGynecologic Oncology Division, Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. tofanwidya@yahoo.com.ORCID 0000-0002-0191-5902
Laila NurannaGynecologic Oncology Division, Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID 0000-0003-1662-1824
Syifa Ainun RahmanGynecologic Oncology Division, Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID 0009-0000-1659-6986
Raysa IrzamiGynecologic Oncology Division, Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID 0009-0001-4078-663X
Andi UtamaKalgen Innolab Laboratory, Jakarta, Indonesia.ORCID 0009-0000-4004-3628
Gatot PurwotoGynecologic Oncology Division, Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID 0000-0001-5019-2707
Eva SuarthanaHealth Technology Assessment Unit, McGill University Health Center, Quebec, Canada.ORCID 0009-0001-2482-1837

Funding

Faculty of Medicine, University of IndonesiaPT KalGen DNA
6 · The paper itself

Abstract

objectiveHuman papillomavirus (HPV) infection is a global public health concern and associated with cervical cancer. HPV genotype mapping has an essential role in prevention and control strategy in developing more suitable HPV vaccine for Indonesia.

methodsThis was a descriptive retrospective cross-sectional study from 2012 until 2022 at Kalgen Laboratory, Jakarta from all over the metropolitan regions. The total 76,413 samples were collected with consecutive sampling, which 694 excluded, thus final samples used were 75,719. HPV DNA test was performed using the polymerase chain reaction (PCR): SPF10-DEIA-LiPA25 methods. HPV genotyping procedures included DNA extraction, PCR using the HPV XpressMatrix kit, and hybridization.

resultsFrom 75,719 samples, 93.4% was negative for intraepithelial lesion or malignancy (NILM). Among 6.6% of total 75,719 samples of abnormal cytology groups, 53.8% were atypical squamous cells of undetermined significance (ASCUS), 32.9% were low grade intraepithelial lesion (LSIL), and 13.3% were high grade intraepithelial lesion (HSIL). The most common high risk HPV genotypes among HSIL were 16, 18, 52, 58, 33, 51, and 53. Single HPV infection was more common compared to multiple infections.

conclusionThis study showed that HR-HPV types among HSIL were 16, 18, 52, 58, 33, 51, and 53. HPV 52 was the most frequent type among NILM, ASCUS, and LSIL. Thus, it could serve as a potential future reference to create a more suitable HPV nonavalent vaccine for Indonesian population based on its different epidemiology.

Indexed as

PapillomaviridaePapillomavirus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsAdolescentAdultAgedCross-Sectional StudiesDNA, ViralFemaleGenotypeHumansIndonesiaMiddle AgedRetrospective StudiesYoung AdultDNA, ViralIndonesiaPapillomavirus InfectionPapillomavirus VaccinesUterine Cervical Neoplasms

Identifiers

PMID40114551
PMCPMC12636126

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.