ArticleJournal of cosmetic dermatology2025
Enhancing Facial Projection: Efficacy and Safety of a Novel Filler Combining Cross-Linked Sodium Hyaluronate Gel With Poly-L-Lactic Acid-b-PEG Microspheres for T-Zone Augmentation.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Long-Term In Vivo Biological Performance of PLLA-b-PEG/HA Filler.Journal of functional biomaterials · 2026Article
- Evaluation of Factors Affecting Bone Resorption After Eyebrow Arch Prosthesis Implantation Based on CT Three-Dimensional Imaging.Aesthetic plastic surgery · 2026Article
- Injectable Scaffolds for Adipose Tissue Reconstruction.Gels (Basel, Switzerland) · 2026Review
- Polycaprolactone versus calcium hydroxylapatite injectable treatments in the T-zone for facial rejuvenation: a clinical comparative study.American journal of translational research · 2026Article
- A Narrative Review of Evolving Techniques in Nonsurgical Rhinoplasty: Risk Profile and Clinical Outcomes of Fillers.Cureus · 2026Review
- Comments on "Real-World Evidence on the Routine Use, Efficacy, and Safety of a Hyaluronic Acid-Based Dermal Filler in the Periorbital Region".Aesthetic plastic surgery · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe nose, eyebrow, and forehead are critical elements of the T-zone, vital for enhancing facial three-dimensionality. Many Asians seek a more contoured and sculpted facial appearance by T-zone augmentation. The novel poly-L-lactic acid microsphere and hyaluronic acid suspension (PLLA-b-PEG/HA) has proven to be a safe and effective dermal filler, making it an appealing choice for individuals aiming for T-zone augmentation.
objectiveTo retrospectively assess the efficacy and safety of PLLA-b-PEG/HA injection into the T-zone for aesthetic enhancement.
methodsFifteen participants were included in this study. A comprehensive clinical evaluation was performed, including measurements of total facial convexity angle and radix height, the FACE-Q scales for satisfaction with the nose, forehead, and eyebrows, the Global Aesthetic Improvement Scale (GAIS), and a 7-item satisfaction scale. Tissue in the peri-eyebrow area was examined 12 months posttreatment for comparison with normal tissues.
resultsSignificant increases in radix height and total facial convexity angle were observed at each follow-up visit (p < 0.05). FACE-Q scores also showed significant improvements from baseline in the eyebrows, forehead, and nose at each posttreatment visit (p < 0.001). The GAIS improvement rate remained high, with 80.00% reported by participants and 86.67% by blinded evaluators 12 months after treatment. The satisfaction rate was 73.3% at this time interval. Pathological examinations demonstrated newly formed collagen fibers and microvessels, with no abnormal pathological structure.
conclusionThe PLLA-b-PEG/HA demonstrates efficacy in enhancing the T-zone (nose, eyebrow, and forehead) with a favorable safety profile.
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