Evidence map›Paper›PMID 40114360›Full record

ArticleThe European journal of neuroscience2025

Resting-State Functional Interactions Between the Action Observation Network and the Mentalizing System.

Luciano Simone, Enrica Pierotti, Eleonora Satta, Cristina Becchio, Luca Turella

Abstract read
In one paragraph

Article in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luciano SimoneDepartment of Medicine and Surgery, University of Parma Via Volturno 39, Parma, Italy.ORCID 0000-0001-7493-6707
Enrica PierottiCenter for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto (TN), Italy.
Eleonora SattaCenter for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto (TN), Italy.
Cristina BecchioDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Luca TurellaCenter for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto (TN), Italy.

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
16 NIH Institutes and CentersEuropean UnionNIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Human social functioning is thought to rely on the action observation network (AON) and the mentalizing system (MS). It is debated whether AON and MS are functionally separate or if they interact. To this end, we combined resting-state connectivity with task-based fMRI to characterize the functional connectome within and between these systems. In detail, we computed resting-state connectivity within and between the AON and MS using single subject-defined regions of interest (ROIs). Our results showed a positive coupling between ROIs within each system and negative coupling between the two systems, supporting the existence of two independent networks at rest. Still, two regions (pSTS, aIFG) showed hybrid coupling, connecting with regions of both systems, suggesting that they might mediate cross-network communication. This characterization of the interplay between MS and AON in the healthy brain might provide the starting point to further investigate aberrant "connectivity" fingerprints associated with neuropsychiatric disorders characterized by impairments in social cognition.

Indexed as

BrainMentalizationNerve NetTheory of MindAdultConnectomeFemaleHumansMagnetic Resonance ImagingMaleRestYoung Adultaction observation networkfMRIfunctional connectivitymentalizing systemresting statesocial cognition

Identifiers

PMID40114360
PMCPMC11926297

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.