Evidence map›Paper›PMID 40114294›Full record

ArticleAutophagy2025

Chaperone-mediated autophagy degrades SERPINA1

Jiayu Lin, Xinyue Wei, Yan Dai, Haorui Lu, Yajian Song, Jiansong Ju, Rihan Wu, Qichen Cao, Hao Yang, Lang Rao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiayu LinCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
Xinyue WeiState Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Yan DaiCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
Haorui LuState Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Yajian SongCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
Jiansong JuCollege of Life Science, Hebei Normal University, Shijiazhuang, China.
Rihan WuDepartment of Radiation Oncology, Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia Autonomous Region, China.
Qichen CaoState Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Hao YangDepartment of Radiation Oncology, Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia Autonomous Region, China.
Lang RaoState Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.ORCID 0000-0002-0207-8659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chaperone-mediated autophagy (CMA) is a specific form of autophagy that selectively targets proteins containing a KFERQ-like motif and relies on the chaperone protein HSPA8/HSC70 for substrate recognition. In SERPINA1/a1-antitrypsin deficiency (AATD), a disease characterized by the hepatic buildup of the SERPINA1

Indexed as

alpha 1-AntitrypsinAutophagyChaperone-Mediated AutophagyMolecular ChaperonesProteolysisStress, Physiologicalalpha 1-Antitrypsin DeficiencyAnimalsHSC70 Heat-Shock ProteinsHumansLysosomal-Associated Membrane Protein 2Micealpha 1-AntitrypsinHSC70 Heat-Shock ProteinsLysosomal-Associated Membrane Protein 2Molecular ChaperonesSERPINA1 protein, humanCellular stresschaperone-mediated autophagyHSPA8/HSC70LAMP2Aprotein degradation

Identifiers

PMID40114294
PMCPMC12282993

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.