ArticleEuropean journal of medical research2025
Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosis.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study explored the correlation between interleukin-1 receptor/Toll-like receptor (IL-1R/TLRs)-mediated inflammatory signaling pathways and the severity of superficial dermatomycosis.
methodsFrom May 2020 to August 2022, 76 patients with superficial dermatomycosis (infected group) and 52 patients without infection (non-infected group) were enrolled. The indicators related to IL-1R/TLRs pathway were analyzed, and the diagnostic value of the combined detection of each index for superficial dermatomycosis and disease severity was analyzed. The correlation between each index and the severity of infection was analyzed.
resultsIL-1β, TLR4, IL-6, and TNF-α in the infected group were higher than those in the non-infected group (P < 0.05). The AUC of IL-1R/TLRs combined detection in the group diagnosed with a superficial dermatomycosis was higher than that of each single detection (P < 0.05). IL-1β, TLR4, IL-6, and TNF-α in the severe group were higher than those in the mild group (P < 0.05). IL-1β, TLR4, IL-6, and TNF-α were positively correlated with the degree of infection (P < 0.05). The AUC of IL-1R/TLRs combined detection was higher than that of each single test (P < 0.05). IL-1β ≥ 2.87 ng/L, TLR4 ≥ 3.12 ng/L, IL-6 ≥ 4.58 ng/L, TNF-α ≥ 70.53 ng/L were the influencing factors of severe superficial dermatomycosis (P < 0.05).
conclusionIL-1R/TLRs pathway is related to the severity of superficial dermatomycosis, and the collective identification of each indicator provides diagnostic insight into infection severity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.