Evidence map›Paper›PMID 40114243›Full record

Observational studyItalian journal of pediatrics2025

Activin-A urine levels correlate with radiological patterns in preterm infants complicated by intraventricular hemorrhage.

Giuseppe Lapergola, Giorgia Gasparroni, Alessandro Graziosi, Darek Gruzfeld, Bashir Moataza, Hanna Aboulgar, Hala Mufeed, Iman Iskander, Giovanni Livolti, Fabio Galvano and 11 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Giuseppe LapergolaNeonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Giorgia GasparroniNeonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Alessandro GraziosiNeonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Darek GruzfeldDepartment of Neonatology and Intensive Care of Neonate, Warsaw University, Warsaw, Poland.
Bashir MoatazaDepartment of Neonatology, Cairo University, Cairo, Egypt.
Hanna AboulgarDepartment of Neonatology, Cairo University, Cairo, Egypt.
Hala MufeedDepartment of Neonatology, Cairo University, Cairo, Egypt.
Iman IskanderDepartment of Neonatology, Cairo University, Cairo, Egypt.
Giovanni LivoltiDepartment of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Catania, Italy.
Fabio GalvanoDepartment of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Catania, Italy.
Gabriella LevantiniNeonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Ebe D'AdamoNeonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Adele Patrizia PrimaveraNeonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Elisabetta BarbanteNeonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Rita SalomoneNeonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Claudia D'EgidioNeonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Chiara StrozziOspedale Cardinal Massaia, Asti, Italy.
Antonio MaconiSocial Security Administration Development and Promotion of Scientific Research Unit, SS Antonio, Biagio and C. Arrigo Hospital, Alessandria, Italy.
Danilo A W GavilanesDepartment of Pediatrics and Neonatology, Maastricht University, Maastricht, The Netherlands.
Ali Saber AbdelhameedDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Diego GazzoloNeonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy. dgazzolo@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo validate the role of Activin A in the early diagnosis and prognosis of preterm newborns at risk for intraventricular hemorrhage and neurological sequelae by means of cerebral ultrasound and magnetic resonance imaging (MRI), currently considered standard of care procedures.

methodsWe conducted an observational case-control study in 46 preterm newborns, 23 with intraventricular hemorrhage (IVH group) and 23 controls matched for gestational age. Standard clinical, laboratory, cerebral ultrasound monitoring procedures and Activin A urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Cerebral MRI was performed at 40-42 weeks of corrected gestational age.

resultsElevated (P < 0.001, for all) Activin A levels were observed in the IVH group at all monitoring time-point. Activin A correlated (P < 0.05, for all) with intraventricular hemorrhage grade on cerebral ultrasound. At the cut-off of 0.08 pg/mL Activin A at 48-h achieved the best sensitivity, specificity, positive/negative predictive values as early predictor of an abnormal MRI pattern (area under the curve: 0.93).

conclusionsThe present data showing a correlation among Activin A, cerebral ultrasound and MRI provide further support to Activin A inclusion in clinical daily management of cases at risk for intraventricular hemorrhage and adverse neurological outcome.

Indexed as

ActivinsCerebral HemorrhageCerebral Intraventricular HemorrhageInfant, Premature, DiseasesBiomarkersCase-Control StudiesFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMagnetic Resonance ImagingMalePrognosisUltrasonographyactivin AActivinsBiomarkersActivin ACerebral ultrasoundIntraventricular hemorrhageMagnetic resonance imagingPreterm infants

Identifiers

PMID40114243
PMCPMC11927341

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.