ArticleEuropean journal of medical research2025
Comparisons of three novel markers for insulin resistance to predict incident cardiovascular disease: a Korean cohort study from three different regions.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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10 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of triglyceride-glucose index and its related parameters with the risk of stroke: a meta-analysis.BMC neurology · 2025Pooled it
- Metabolic score for insulin resistance and the incidence of cardiovascular disease: a meta-analysis of cohort studies.Frontiers in endocrinology · 2025Pooled it
- Global prevalence of insulin resistance in the adult population: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Association of Triglyceride-Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Association of peripheral insulin resistance with cognitive impairment in patients with non-disabling ischemic cerebrovascular events and the mediating role of chronic inflammatory biomarkers.European journal of medical research · 2026Article
- Association of Composite Metabolic Indices and Oxidative Stress Biomarkers with Coronary Atherosclerosis Detected by CT Angiography in Premenopausal Women with Metabolic Syndrome.Vascular health and risk management · 2026Article
- Combined effect of triglyceride-glucose index and glucose disposal rate on cardio-cerebrovascular disease.PloS one · 2026Article
- Propensity score analysis of triglyceride-glucose index in newly diagnosed patients with essential hypertension as a predictor of microalbuminuria.Frontiers in endocrinology · 2026Observational
- Evaluation of four insulin resistance surrogate indicators for predicting short-term mortality in critically ill patients with ischemic stroke: a nationwide retrospective cohort study.Cardiovascular diabetology · 2025Article
- A structured list of laboratory tests for screening the possible causes of small fiber neuropathy in clinical practice.Frontiers in neurology · 2025Review
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Abstract
backgroundCardiovascular disease (CVD) is a crucial human health challenge. Previous studies have shown an association between CVD and the triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), and metabolic score for insulin resistance (METS-IR). However, a comparison of these novel markers for predicting CVD is not well known. Therefore, we aimed to assess the value of TyG, AIP, and METS-IR in predicting the incidence of CVD in three large cohorts of Korean adults.
methodsData from 28 437 participants in the Korean Genome and Epidemiology Study (KoGES) and Korea Health Insurance Review and Assessment (HERAS-HIRA) were assessed. The participants were divided into four groups according to the quartiles of TyG index: ln ([triglyceride × fasting plasma glucose]/2), AIP calculated as log (triglyceride/high-density lipoprotein cholesterol), and METS-IR index: (ln ([2 × fasting plasma glucose] + triglyceride) × body mass index)/(ln [high-density lipoprotein cholesterol-cholesterol]). We prospectively assessed the hazard ratios (HRs) with 95% confidence intervals (CIs) for CVD using multivariate Cox proportional hazard regression models after adjusting for potential confounding variables.
resultsDuring the follow-up period, 987 participants (3.5%) developed CVD. Compared with the referent first quartiles, the highest TyG index, AIP, and METS-IR quartiles, with HRs of 1.73 (95% CI 1.41-2.12), 1.47 (95% CI 1.19-1.80), and 2.61 (95% CI 1.83-3.72), respectively, significantly predicted future CVD, after adjusting for age, sex, and body mass index. When comparing the three biomarkers for insulin resistance, the TyG index and METS-IR showed similar predictive values, whereas AIP had a lower significance in predicting CVD.
conclusionsBased on the current findings, novel surrogate markers of insulin resistance, particularly METS-IR and TyG index, may help predict the risk of CVD in Koreans.
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