ArticleLipids in health and disease2025
Association between red blood cell fatty acids composition and risk of esophageal cancer: a hospital-based case-control study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background& aims: Esophageal cancer (EC) is a tumor type with high invasiveness and poor prognosis, attracting scientists' attention to its pathogenesis and etiology. Given the limited evidence and conflicting findings regarding the association between EC risk and RBC fatty acids, we aimed to evaluate this association.
methodsThe study utilized gas chromatography to analyze RBC fatty acids in 158 EC patients and 224 controls. Multivariable conditional logistic regression and restricted cubic spline analysis were employed to assess the association between EC risk and RBC fatty acids, as well as to determine the odds ratio with a 95% confidence interval (OR, 95% CI) for this association.
resultsHigher levels of total n-3 polyunsaturated fatty acids (n-3 PUFA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and n-3 index were associated with lower odds of being an EC case [OR
conclusionThe different types of RBC fatty acids may significantly influence susceptibility to EC. Higher levels of total n-3 PUFA in RBC, specifically DHA and EPA, were associated with lower odds of being an EC case, while higher levels of C20:4n-6, C18:0, and C16:0 were associated with higher odds.
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