Evidence map›Paper›PMID 40114196›Full record

ArticleJournal of nanobiotechnology2025

Selenium nanoparticles activate selenoproteins to mitigate septic lung injury through miR-20b-mediated RORγt/STAT3/Th17 axis inhibition and enhanced mitochondrial transfer in BMSCs.

Wan-Jie Gu, Feng-Zhi Zhao, Wei Huang, Ming-Gao Zhu, Hai-Yan Huang, Hai-Yan Yin, Tianfeng Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wan-Jie Gu *Department of Intensive Care Unit, The First Affiliated Hospital, Department of Chemistry, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, Jinan University, Guangzhou, China.
Feng-Zhi Zhao *Department of Intensive Care Unit, The First Affiliated Hospital, Department of Chemistry, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, Jinan University, Guangzhou, China.
Wei HuangDepartment of Intensive Care Unit, The First Affiliated Hospital, Department of Chemistry, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, Jinan University, Guangzhou, China.
Ming-Gao ZhuDepartment of Intensive Care Unit, The First Affiliated Hospital, Department of Chemistry, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, Jinan University, Guangzhou, China.
Hai-Yan HuangDepartment of Intensive Care Unit, The First Affiliated Hospital, Department of Chemistry, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, Jinan University, Guangzhou, China.
Hai-Yan YinDepartment of Intensive Care Unit, The First Affiliated Hospital, Department of Chemistry, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, Jinan University, Guangzhou, China. haiyanyin1867@126.com.
Tianfeng ChenDepartment of Intensive Care Unit, The First Affiliated Hospital, Department of Chemistry, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, Jinan University, Guangzhou, China. tchentf@jnu.edu.cn.

Funding

National Natural Science Foundation of China 82072232Science and Technology Projects in Guangzhou 2025A03J3472Science and Technology Projects in Guangzhou 2025A03J4248
6 · The paper itself

Abstract

Sepsis-induced acute lung injury (ALI) remains a critical clinical challenge with complex inflammatory pathogenesis. While bone marrow mesenchymal stem cells (BMSCs) demonstrate therapeutic potential through anti-inflammatory and cytoprotective effects, their age-related functional decline limits clinical utility. This study developed chitosan-functionalized selenium nanoparticles (SeNPs@CS, 100 nm) to rejuvenate BMSCs through miR-20b-mediated selenoprotein biosynthesis. Mechanistic investigations revealed that SeNPs@CS-treated BMSCs exhibited enhanced mitochondrial transfer capacity, delivering functional mitochondria to damaged alveolar epithelial cells (AECII) for cellular repair. Concurrently, miR-20b upregulation suppressed the RORγt/STAT3/Th17 axis, reducing pro-inflammatory Th17 cell differentiation in CD4

Indexed as

Acute Lung InjuryMesenchymal Stem CellsMicroRNAsMitochondriaNanoparticlesSeleniumSelenoproteinsSepsisAnimalsCell DifferentiationChitosanMaleMiceMice, Inbred C57BLNuclear Receptor Subfamily 1, Group F, Member 3STAT3 Transcription FactorChitosanMicroRNAsNuclear Receptor Subfamily 1, Group F, Member 3SeleniumSelenoproteinsSTAT3 Transcription FactorAcute lung injuryBMSCsMitochondrial transferRORγt/STAT3SeleniumTh17

Identifiers

PMID40114196
PMCPMC11924768

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.