SynthesisBMC oral health2025
Influence of alloplastic materials, biologics, and their combinations, along with defect characteristics, on short-term intrabony defect surgical treatment outcomes: a systematic review and network meta-analysis.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Astaxanthin as an Antioxidant and Anti-Inflammatory Agent in Human Health: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Exosome-based therapeutics in bone regeneration: from fundamental biology to clinical translation.Stem cell research & therapy · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundTreating periodontal intrabony defects remains challenging, alloplast materials and biologics are increasingly utilized to improve regeneration outcomes. However, comparative efficacy on alloplast materials remains limited. This study aimed to evaluate the effectiveness of alloplastic materials, both alone and combined with biologics, in treating periodontal defects.
methodsA systematic search of PubMed, Scopus, and CENTRAL identified 74 eligible randomized controlled trials. Meta-analysis assessed data heterogeneity based on defect depth and morphology, classifying defects by wall configuration. Network meta-analysis compared clinical attachment level (CAL) gain, probing depth (PD) reduction, and radiographic linear bone (RLB) gain up to 12 months. Risk of bias was evaluated using the Cochrane Risk of Bias 2 tool, and confidence in network meta-analysis was graded using CINeMA.
resultsDefect depth and morphology significantly impacted heterogeneity outcomes at 6 months, but by 12 months, differences across treatments were less significant. Biphasic calcium phosphate (BCP) and nanocrystalline hydroxyapatite (nHA) showed notable improvements in CAL gain, PD reduction, and RLB gain. Combining nHA with platelet-rich fibrin (PRF) outperformed open flap debridement (mean differences at 6 months for CAL gain: 1.37 mm, PD reduction: 1.52 mm and RLB gain: 1.39 mm). SUCRA ranked bioglass and BCP highest for single treatments, while bioglass with platelet-rich plasma and nHA + PRF excelled among combinations.
conclusionsAlloplastic materials, particularly BCP and nHA, significantly enhance periodontal treatment outcomes, especially when combined with biologics like PRF. Defect depth and morphology influence treatment efficacy at 6 months, though by 12 months, treatment outcomes converge, underscoring the value of early, tailored strategies in periodontal therapy.
trial registrationNot applicable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.