Evidence map›Paper›PMID 40114120›Full record

SynthesisBMC medical genomics2025

A comprehensive integration of data on the association of ITPKC polymorphisms with susceptibility to Kawasaki disease: a meta-analysis.

Atefeh Habibi, Hanieh Talebi, Reza Bahrami, Mohammad Golshan-Tafti, Amirhossein Shahbazi, Seyed Alireza Dastgheib, Azadeh Tahooni, Maryam Vafapour, Heewa Rashnavadi, Melina Pourkazemi and 3 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC medical genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Atefeh HabibiDepartment of Pediatrics, Hakim Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hanieh TalebiClinical Research Development Unit, Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran. talebi_hanieh@yahoo.com.
Reza BahramiNeonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Golshan-TaftiDepartment of Pediatrics, School of Medicine, Islamic Azad University of Yazd, Yazd, Iran.
Amirhossein ShahbaziStudent Research Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Seyed Alireza DastgheibDepartment of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Azadeh TahooniDepartment of Cardiology, Firoozgar Hospital Research Center, Iran University of Medical Sciences, Tehran, Iran.
Maryam VafapourDepartment of Pediatrics, Firoozabadi Clinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran.
Heewa RashnavadiStudent Research Committee, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Melina PourkazemiStudent Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Maryam YeganegiDepartment of Obstetrics and Gynecology, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Elnaz SheikhpourHematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein NeamatzadehMother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to conduct a comprehensive meta-analysis of existing research to define clear associations between variations in the ITPKC gene and the risk of developing Kawasaki disease (KD).

methodsA comprehensive search was conducted across multiple databases, including but not limited to PubMed, Scopus, EMBASE, and CNKI, up to June 1, 2024, to gather relevant information. This search utilized keywords and MeSH terms related to hyperbilirubinemia and genetic factors. The inclusion criteria encompassed original case-control, longitudinal, or cohort studies. Correlations were analyzed as odds ratios (ORs) with 95% confidence intervals (CIs) using Comprehensive Meta-Analysis software.

resultsEighteen case-control studies with 5,434 KD cases and 9,419 controls were analyzed. Of these, ten studies assessed 3,129 KD cases and 6,172 controls for the rs28493229 variant, four examined 1,039 cases and 1,688 controls for the rs2290692 variant, two focused on 595 cases and 820 controls for the rs7251246 variant, and two investigated 671 cases and 739 controls for the rs10420685 variant. Results showed a significant association between the rs28493229 polymorphism and increased KD risk across all five genetic models. Subgroup analysis indicated this polymorphism correlates with KD susceptibility in Asians but not in the Chinese population. In contrast, no associations were found between the rs2290692, rs7251246, and rs10420685 polymorphisms and KD risk.

conclusionsOur pooled data indicate a significant association between the ITPKC rs28493229 polymorphism's minor allele and an increased risk of developing KD, suggesting this variant may enhance susceptibility. Conversely, SNPs rs2290692, rs7251246, and rs10420685 do not demonstrate a statistically significant relationship with KD.

Indexed as

Genetic Predisposition to DiseaseMucocutaneous Lymph Node SyndromePhosphotransferases (Alcohol Group Acceptor)Polymorphism, Single NucleotideCase-Control StudiesHumansInositol 1,4,5-trisphosphate 3-kinasePhosphotransferases (Alcohol Group Acceptor)Coronary arteryInflammationITPKCKawasaki diseasePolymorphism

Identifiers

PMID40114120
PMCPMC11927170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.