Evidence map›Paper›PMID 40114023›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2025

Unbound bilirubin and bilirubin-albumin binding levels of Japanese neonates.

Kazuki Nishizawa, Yoshinori Katayama, Yong-Kye Lee

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kazuki NishizawaDepartment of Neonatology, Takatsuki General Hospital, Takatsuki, Osaka, Japan.
Yoshinori KatayamaDepartment of Neonatology, Takatsuki General Hospital, Takatsuki, Osaka, Japan. katayamayo@gmail.com.ORCID http://orcid.org/0000-0003-4822-5535
Yong-Kye LeeDepartment of Pediatrics, Aijinkai Rehabilitation Hospital, Takatsuki, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine postnatal changes in total serum bilirubin (TB), unbound bilirubin (UB), and bilirubin-binding affinity of albumin (Ka) among Japanese newborns. STUDY

designIn a retrospective study, we evaluated for serum TB, UB, and albumin (Alb) levels, and their calculated UB/TB ratios, and Ka in 786 neonates born ≥36 weeks' gestation and analyzed to subcategories of three postnatal epochs: first, second, and ≥third weeks.

resultTB levels were significantly higher (p < 0.01) at age ≥three weeks, while UB levels were significantly higher (p < 0.01) in the first week. UB/TB ratios were significantly lower while calculated Ka values were significantly higher as age-in-weeks increased (p < 0.01).

conclusionHyperbilirubinemia in the first and second weeks of age in neonates born ≥36 weeks' gestation is associated with higher UB levels or UB/TB ratios with lower Ka and may potentially contribute to the risk of developing bilirubin neurotoxicity with aggravated variations in bilirubin, albumin and Ka.

Indexed as

BilirubinHyperbilirubinemia, NeonatalSerum AlbuminEast Asian PeopleFemaleGestational AgeHumansInfant, NewbornInfant, PrematureJapanMaleRetrospective StudiesBilirubinSerum Albumin

Identifiers

PMID40114023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.