ArticleCommunications biology2025
Phylogenetic history and temperature adaptation contribute to structural and functional stability of proteins in marine mollusks.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A naturally synonymous mutation modulates an ERK-centered regulatory network to mediate thermotolerance divergence in Crassostrea oysters.Communications biology · 2026Article
- Genome-wide transcriptomic analysis reveals autophagy and HSP70-mediated mechanisms underlying thermal stress adaptation in Mytilus coruscus.BMC genomics · 2025Article
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6 authors.
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Abstract
Teasing apart the influences of phylogenetic history from thermal adaptation is a focal challenge in understanding the factors driving change in protein stability. This study conducted comprehensive comparative analyses between the phylogenetic relationships and functional/structural stabilities at protein and mRNA levels of cytosolic malate dehydrogenase (cMDH) orthologs of 41 marine mollusks living at widely different environmental temperatures. At the protein level, a significant negative correlation between adaptation temperature and heat-induced movements of the cMDH backbone was found. The movement fluctuation of individual residue varied similarly among cMDH orthologs. At the mRNA level, the free energy that occurs during the formation of the ensemble of mRNA secondary structure was significantly positively correlated with adaptation temperature. The fraction of guanine and cytosine increased with adaptation temperature. The proportion of variance in adaptation temperature that can be explained by the thermal stability (R
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