Evidence map›Paper›PMID 40113943›Full record

ArticleScientific reports2025

Lab-in-a-Fiber detection and capture of cells.

João C Varela, Achar V Harish, Pawel Maniewski, Timothy Gibbon, Oana Tudoran, Rainer Heuchel, Matthias Löhr, Walter Margulis, Aman Russom, Fredrik Laurell

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

João C Varela *Division of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden. joao.varela@scilifelab.se.
Achar V Harish *Department of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden.
Pawel ManiewskiDepartment of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden.
Timothy GibbonResearch Institutes of Sweden (RISE), Stockholm, Sweden.
Oana TudoranDivision of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.
Rainer HeuchelDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Matthias LöhrDepartment of Cancer Medicine, Division for Upper GI, Karolinska University Hospital, Stockholm, Sweden.
Walter MargulisDepartment of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden.
Aman RussomDivision of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.
Fredrik LaurellDepartment of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A lab-in-a-fiber component was fabricated using an optical fiber and a fiber capillary. It was used in a test suspension of fluorescently labeled and unlabeled cells and enabled detection of the labeled cells. Subsequently the labeled cells were selectively collected via suction into the capillary. A novel sampling technique reduced photobleaching of the labeled cells, extending the measurement time. The collected cells remained viable for downstream analysis. This platform's low fabrication cost, simplicity, compatibility with standard laboratory equipment, and capacity for fully automated cell capture highlights its potential for future applications in minimally invasive sample collection and point-of-care diagnostics. We demonstrate this LiF device to showcase the capability of optical fiber technology in creating low-cost, low-complexity cancer diagnostic devices. Furthermore, the LiF device holds promise for in vivo diagnostics, facilitating cell isolation and analysis.

Indexed as

Cell SeparationFiber Optic TechnologyOptical FibersCell Line, TumorHumansCancer diagnosticsCell captureCell detectionLab-in-a-Fiber

Identifiers

PMID40113943
PMCPMC11926341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.