ArticleScientific reports2025
Brain handedness associations depend on how and when handedness is measured.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder.Psychological medicine · 2026Article
- Replicability of Functional Brain Networks: A Study Through the Lens of Seven Resting-State Networks.Human brain mapping · 2026Article
- The Association Between Laterality and Stroke Severity: A Cross-Sectional Study.Health science reports · 2026Article
- Article
- Study on the differences in peripheral fatigue responses elicitation effects of bench press training with different loads and tempos based on electromyography and motion sensors.Frontiers in physiology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Hand preference is ubiquitous, intuitive, and often simplified to right- or left-handed. Accordingly, differences between right- and left-handed individuals in the brain have been established. Nevertheless, considering handedness as a binarized construct fails to capture the variability of brain-handedness associations across different domains or activities. Further, hand-use changes across generations (e.g., letter writing vs. texting) such that individuals of different ages live in different environments. As a result, brain-handedness associations may depend on how and when handedness is measured. We used two large datasets, the Human Connectome Project-Development (HCP-D; n = 465; age = 5-21 years) and Human Connectome Project-Aging (HCP-A; n = 368; age = 36-100 years), to investigate generational differences in brain-handedness associations. Nine items from the Edinburgh Handedness Inventory were associated with resting-state functional connectomes. We show that brain-handedness associations differed across the two cohorts. Moreover, these differences depended on the way handedness was measured. Given that brain-handedness associations differ across handedness measures and datasets, we caution against a one-size-fits-all approach to neuroimaging studies of this complex trait.
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