Evidence map›Paper›PMID 40113814›Full record

ArticleNature communications2025

Transport and InsP

Qinyu Zhu, Madeleine F Yaggi, Nikolaus Jork, Henning J Jessen, Melinda M Diver

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Structures of the sodium-coupled phosphate importer SLC34A2 reveal a distinct architecture and gating mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. The Diphosphoinositol Polyphosphate Phosphohydrolase 1 family binds IPInternational journal of biological macromolecules · 2026
    Article
  5. Phosphate homeostasis and endocrine regulators.Pediatric nephrology (Berlin, Germany) · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qinyu ZhuStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0001-7020-2044
Madeleine F YaggiStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nikolaus JorkDepartment of Chemistry and Pharmacy, Institute for Organic Chemistry, and CIBSS - Centre for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany.
Henning J JessenDepartment of Chemistry and Pharmacy, Institute for Organic Chemistry, and CIBSS - Centre for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-1025-9484
Melinda M DiverStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. diverm2@mskcc.org.ORCID http://orcid.org/0000-0001-5037-7322

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Weill Cornell Initiative for Maximizing Student DevelopmentR25GM130494 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CARRASCO, YAZMIN PAULINA, CESARMAN, ETHEL · 2019 to 2023
$2.4M
Deutsche Forschungsgemeinschaft (German Research Foundation) CIBSS, EXC-2189, 390939984Division of Cancer Prevention, National Cancer Institute (NCI Division of Cancer Prevention) P30-CA008748NCI NIH HHS P30 CA008748NIGMS NIH HHS R25 GM130494U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) Weill Cornell IMSD T32
6 · The paper itself

Abstract

Inorganic phosphate (Pi) has essential metabolic and structural roles in living organisms. The Pi exporter, XPR1/SLC53A1, is critical for cellular Pi homeostasis. When intercellular Pi is high, cells accumulate inositol pyrophosphate (1,5-InsP

Indexed as

Inositol PhosphatesPhosphatesReceptors, Cytoplasmic and NuclearReceptors, G-Protein-CoupledBiological TransportCryoelectron MicroscopyHEK293 CellsHumansModels, MolecularProtein BindingProtein DomainsProtein MultimerizationXenotropic and Polytropic Retrovirus ReceptorInositol PhosphatesPhosphatesReceptors, Cytoplasmic and NuclearReceptors, G-Protein-CoupledXenotropic and Polytropic Retrovirus ReceptorXPR1 protein, human

Identifiers

PMID40113814
PMCPMC11926068

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.