ArticleNature communications2025
Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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13citing papers in PubMed
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Who cites it
13 citing papers in PubMed.
- Hypothalamic neurovascular and extracellular matrix remodeling: Cellular niche orchestration of immune-metabolic adaptation to nutritional stress.Reviews in endocrine & metabolic disorders · 2026Review
- Review
- Restoring the CD226 in CD8Cell death & disease · 2026Article
- Ovarian hormones and high-fat diet duration distinctively modulate hypothalamic chemokine profile.Journal of neuroendocrinology · 2026Article
- Microglia and neuroinflammation: function, heterogeneity, and crosstalk.Cellular & molecular immunology · 2026Review
- MASH-Associated T Cell Activation and Neuroinflammation: Evidence for a Hepatosystemic Immune Axis.Seminars in liver disease · 2026Review
- Redefining the timeline: a three-phase framework of hypothalamic microinflammation in metabolic disease.Reviews in endocrine & metabolic disorders · 2026Review
- Bridging exercise biology and immunometabolism: A novel irisin pathway toward next-generation metabolic and neurodegenerative therapies.Metabolism open · 2026Review
- Obesity as a catalyst for neurodegeneration.Nature metabolism · 2026Review
- Regulatory T cells in intracerebral hemorrhage: mechanisms of immunomodulation and therapeutic potential.Frontiers in immunology · 2026Review
- Mechanisms of dyslipidemia-induced erectile dysfunction: a narrative review.Frontiers in endocrinology · 2026Review
- Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity.The Journal of biological chemistry · 2025Review
- Regulatory T cell transdifferentiation as a driver of obesity and diabetes.Frontiers in immunology · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
30 authors.
Maike BeckerResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-6416-4213
Stefanie KälinGerman Center for Diabetes Research (DZD), Munich, Germany.
Anne H NeubigResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-1770-6416
Michael LauberResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany.
Daria OpalevaResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-3947-7060
Hannah HippResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany.
Victoria K SalbResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany.
Verena B OttGerman Center for Diabetes Research (DZD), Munich, Germany.
Beata LegutkoInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Munich and Division of Metabolic Diseases, Technische Universität München, Munich, Germany.
Roland E KälinDepartment of Neurosurgery, Medical Faculty, Johannes Kepler University Linz, Linz, Austria.
Markus HippichGerman Center for Diabetes Research (DZD), Munich, Germany.ORCID http://orcid.org/0000-0001-6253-2596
Martin G SchermResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany.
Lucas F R NascimentoResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany.
Isabelle SerrResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany.
Fabian HospDepartment of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Alexei NikolaevInstitute for Molecular Medicine, Universitätsmedizin der Johannes-Gutenberg-Universität, Mainz, Germany.
Alma MohebianyInstitute for Molecular Medicine, Universitätsmedizin der Johannes-Gutenberg-Universität, Mainz, Germany.ORCID http://orcid.org/0000-0001-9818-6867
Martin KruegerInstitute for Anatomy, Leipzig University, Leipzig, Germany.
Bianca FlachmeyerInstitute for Anatomy, Leipzig University, Leipzig, Germany.
Michael W PfafflAnimal Physiology and Immunology, Technische Universität München, Freising-Weihenstephan, Germany.ORCID http://orcid.org/0000-0002-3192-1019
Bettina HaaseGenomics Core Facility, EMBL European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9811-473X
Chun-Xia YiDepartment of Endocrinology and Metabolism, Amsterdam University Medical Center, location AMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1184-4615
Sarah DietzenInstitute of Immunology, Johannes Gutenberg University Mainz, Mainz, Germany.
Tobias BoppInstitute of Immunology, Johannes Gutenberg University Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0002-3232-8065
Stephen C WoodsMetabolic Diseases Institute, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA.
Ari WaismanInstitute for Molecular Medicine, Universitätsmedizin der Johannes-Gutenberg-Universität, Mainz, Germany.ORCID http://orcid.org/0000-0003-4304-8234
Benno WeigmannDepartment of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany.ORCID http://orcid.org/0000-0002-2398-0844
Matthias MannDepartment of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID http://orcid.org/0000-0003-1292-4799
Matthias H TschöpGerman Center for Diabetes Research (DZD), Munich, Germany. matthias.tschoep@helmholtz-munich.de.ORCID http://orcid.org/0000-0002-4744-371X
Carolin DanielResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany. carolin.daniel@helmholtz-munich.de.ORCID http://orcid.org/0000-0003-4698-7069
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) 490846870 - TRR355/1 TPA09Deutsche Forschungsgemeinschaft (German Research Foundation) 490846870 - TRR355/1 TPB02Deutsche Forschungsgemeinschaft (German Research Foundation) 490846870 - TRR355/1 TPB05Deutsche Forschungsgemeinschaft (German Research Foundation) DFG-CRC1811 (B02)Deutsche Forschungsgemeinschaft (German Research Foundation) Project-ID 210592381 - SFB 1054 (B11)Deutsche Forschungsgemeinschaft (German Research Foundation) project number 490846870 - TRR355/1 TPA02European Foundation for the Study of Diabetes (EFSD) EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research 2020Helmholtz Association Excellence Program for Outstanding Female ScientistsHelmholtz Association Initiative and Networking Fund
Abstract
The hypothalamus in the central nervous system (CNS) has important functions in controlling systemic metabolism. A calorie-rich diet triggers CNS immune activation, impairing metabolic control and promoting obesity and Type 2 Diabetes (T2D), but the mechanisms driving hypothalamic immune activation remain unclear. Here we identify regulatory T cells (Tregs) as key modulators of hypothalamic immune responses. In mice, calorie-rich environments activate hypothalamic CD4
Indexed as
HypothalamusT-Lymphocytes, RegulatoryAnimalsDiabetes Mellitus, Type 2MacrophagesMaleMiceMice, Inbred C57BLMicrogliaObesityReceptors, CCR7Receptors, CXCR3T-Box Domain ProteinsCcr7 protein, mouseReceptors, CCR7Receptors, CXCR3T-Box Domain Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.