Evidence map›Paper›PMID 40113741›Full record

ArticleAnnals of intensive care2025

Severe hemoptysis associated with lung cancer in the ICU: recurrence and outcome.

Raphael Salvayre, Clément Hanotin, Antoine Parrot, Julien Dessajan, Alexandre Elabbadi, Nicolas Pasquier-Meunier, Muriel Fartoukh, Matthias Barral, Aude Gibelin

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Article in Annals of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Coagulation Abnormalities in Lung Cancer: Diagnostic Challenges and Therapeutic Perspectives.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raphael SalvayreAssistance Publique-Hôpitaux de Paris (AP-HP), Service de Médecine Intensive Réanimation, Hôpital Tenon, Sorbonne Université, 4 Rue de la Chine, 75020, Paris, France.
Clément HanotinAssistance Publique-Hôpitaux de Paris, Service de Radiologie, Hôpital Tenon, Sorbonne Université, Paris, France.
Antoine ParrotAssistance Publique-Hôpitaux de Paris, Service de Pneumologie et Oncologie Thoracique, Hôpital Tenon, Sorbonne Université, Paris, France.
Julien DessajanAssistance Publique-Hôpitaux de Paris (AP-HP), Service de Médecine Intensive Réanimation, Hôpital Tenon, Sorbonne Université, 4 Rue de la Chine, 75020, Paris, France.
Alexandre ElabbadiAssistance Publique-Hôpitaux de Paris (AP-HP), Service de Médecine Intensive Réanimation, Hôpital Tenon, Sorbonne Université, 4 Rue de la Chine, 75020, Paris, France.
Nicolas Pasquier-MeunierAssistance Publique-Hôpitaux de Paris (AP-HP), Service de Médecine Intensive Réanimation, Hôpital Tenon, Sorbonne Université, 4 Rue de la Chine, 75020, Paris, France.
Muriel FartoukhAssistance Publique-Hôpitaux de Paris (AP-HP), Service de Médecine Intensive Réanimation, Hôpital Tenon, Sorbonne Université, 4 Rue de la Chine, 75020, Paris, France.
Matthias BarralAssistance Publique-Hôpitaux de Paris, Service de Radiologie, Hôpital Tenon, Sorbonne Université, Paris, France.
Aude GibelinAssistance Publique-Hôpitaux de Paris (AP-HP), Service de Médecine Intensive Réanimation, Hôpital Tenon, Sorbonne Université, 4 Rue de la Chine, 75020, Paris, France. aude.gibelin@aphp.fr.ORCID http://orcid.org/0000-0002-2114-9520

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemoptysis is a life-threatening event in the course of lung cancer (LC). The management of the most severe episodes of hemoptysis include medical measures and vascular interventional radiology (VIR). There are few data on initial clinical and radiological features associated with early bleeding recurrence, and its prognostic significance.

methodsA monocenter retrospective study involving patients admitted to the intensive care unit (ICU) between 2009 and 2020 for severe hemoptysis (SH) associated with LC and requiring VIR.

resultsDuring the study period, 130 patients (85% males; 59.5 ± 5.3 yrs) with SH and non-small cell (78%) or small-cell (18%) LC were analysed. SH was inaugural in half of cases. A lower respiratory tract infection (LRTI) was microbiologically documented in 39% of cases. All patients received a first-line VIR, including systemic bronchial and non-bronchial arteriography with embolisation (n = 117) and/or pulmonary arterial vaso-occlusion (n = 20). Bleeding recurred in 34% cases, after 1 day [1-3] of initial VIR attempt. Overall, the 28-day, 6-month and 12-month mortality rates were 25.3%, 47.7% and 63%, respectively. Intravenous terlipressin prior to VIR (OR 4.43, p = 0.001) and LRTI (OR 2.93; p = 0.007) were independently associated with bleeding recurrence. Tumoral cavitation (HR 3.37; p = 0.004), Staphylococcus aureus infection (HR 8.3; p = 0.005) and bleeding recurrence (HR 2.68; p = 0.01) were independently associated with one-year mortality.

conclusionLung cancer-related SH is associated with a high rate of bleeding recurrence and a poor prognosis. The association of Staphylococcus aureus infection with recurrence and mortality raises the potential interest of the administration of antibacterial treatment in that context.

Indexed as

Bronchopulmonary cancerHemoptysisIntensive care unitOutcome

Identifiers

PMID40113741
PMCPMC11925840

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.