Evidence map›Paper›PMID 40113665›Full record

ReviewAnnals of intensive care2025

Management of severe acute encephalopathy in the ICU: an expert consensus statement from the french society of intensive care medicine.

Romain Sonneville, Eric Azabou, Pierre Bailly, Sarah Benghanem, Gilles De Almeida Cardoso, Pierre Claquin, David Cortier, Augustin Gaudemer, Bertrand Hermann, Pierre Jaquet and 12 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Observational
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Romain SonnevilleMédecine intensive reanimation, Hôpital Bichat - Claude Bernard, 46 Rue Henri Huchard, 75877, Paris Cedex, France. romain.sonneville@aphp.fr.ORCID http://orcid.org/0000-0003-0245-309X
Eric AzabouClinical Neurophysiology and Neuromodulation Unit, Departments of Physiology and Critical Care Medicine, Inserm UMR 1173, Infection and Inflammation (2I), Raymond Poincaré Hospital, Assistance Publique- Hôpitaux de Paris, University of Versailles Saint-Quentin en Yvelines (UVSQ), Paris-Saclay University, Garches, Paris, France.
Pierre BaillyMédecine intensive reanimation, CHU de Brest, Brest, France.
Sarah BenghanemMédecine intensive reanimation, Hôpital Cochin, Paris, France.
Gilles De Almeida CardosoService de reanimation medico-chirurgicale Hôpital Foch, Suresnes, France.
Pierre ClaquinMédecine intensive reanimation, Hôpital Bichat - Claude Bernard, 46 Rue Henri Huchard, 75877, Paris Cedex, France.
David CortierService de reanimation medico-chirurgicale Hôpital Foch, Suresnes, France.
Augustin GaudemerImagerie medicale, Hôpital Bichat - Claude Bernard, Paris, France.
Bertrand HermannMédecine intensive reanimation, Hôpital Européen Georges Pompidou, Paris, France.
Pierre JaquetMédecine intensive reanimation, Hôpital Delafontaine, Saint Denis, France.
Virginie LambrecqDMU Neurosciences, Département de Neurophysiologie Clinique, Paris Brain Institute - ICM, Inserm U1127, Sorbonne Université, APHP, Hôpital Pitié-Salpêtrière, CNRS-UMR7225, Paris, France.
Camille LegouyAnesthesia and intensive care department, Pole Neuro, GHU Paris Psychiatrie et Neurosciences, Sainte Anne Hospital, Paris, France.
Stéphane LegrielMédecine intensive reanimation, CH Mignot, Le Chesnay, France.
Thomas RambaudService de reanimation medico-chirurgicale Hôpital Foch, Suresnes, France.
Benjamin RohautDMU Neurosciences - Neuro ICU, PICNIC-Lab, Sorbonne Université, APHP, Hôpital de la Pitié Salpêtrière, Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Benjamine SartonService de reanimation Polyvalente Hôpital Purpan, CHU de Toulouse, Toulouse, France.
Stein SilvaService de reanimation Polyvalente Hôpital Purpan, CHU de Toulouse, Toulouse, France.
Tarek SharsharAnesthesia and intensive care department, Pole Neuro, GHU Paris Psychiatrie et Neurosciences, Sainte Anne Hospital, Paris, France.
Fabio Silvio TacconeService des Soins intensifs, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgique.
Dominique VodovarCentre Antipoison de Paris, AP-HP, Hôpital Fernand Widal, 75010, Paris, France.
Nicolas WeissDMU Neurosciences - Neuro ICU, PICNIC-Lab, Sorbonne Université, APHP, Hôpital de la Pitié Salpêtrière, Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Charles CerfService de reanimation medico-chirurgicale Hôpital Foch, Suresnes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute encephalopathy in the ICU poses significant diagnostic, therapeutic, and prognostic challenges. Standardized expert guidelines on acute encephalopathy are needed to improve diagnostic methods, therapeutic decisions, and prognostication.

methodsThe experts conducted a review of the literature, analysed it according to the GRADE (Grading of Recommendation, Assessment, Development and Evaluation) methodology and made proposals for guidelines, which were rated by other experts. Only expert opinions with strong agreement were selected.

resultsThe synthesis of expert work and the application of the GRADE method resulted in 39 recommendations. Among the 39 formalized recommendations, 1 had a high level of evidence (GRADE 1 +) and 10 had a low level of evidence (GRADE 2 + or 2-). These recommendations describe indication for ICU admission, use of clinical scores and EEG for diagnosis, detection of complications, and prognostication. The remaining 28 recommendations were based on expert consensus. These recomandations describe common indications for blood and CSF studies, neuroimaging, use of neuromonitoring, and provide guidelines for management in the acute phase.

conclusionThis expert consensus statement aims to provide a structured framework to enhance the consistency and quality of care for ICU patients presenting with acute encephalopathy. By integrating high-quality evidence with expert opinion, it offers a pragmatic approach to addressing the complex nature of acute encephalopathy in the ICU, promoting best practices in patient care and facilitating future research in the field.

Identifiers

PMID40113665
PMCPMC11926322

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.