ArticleEuropean journal of nuclear medicine and molecular imaging2025
Diagnostic accuracy in NSCLC lymph node staging with Total-Body and conventional PET/CT.
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- From sensitivity gain to clinical decisions: total-body and long-axial-field-of-view PET/CT for diagnosis and image-based management in oncology and systemic disease.Annals of nuclear medicine · 2026Review
- The cost of knowing: should frozen section pathology be used routinely for the assessment of lymph nodes in clinical stage IA non-small cell lung cancer?Journal of thoracic disease · 2026Article
- Review
- Preoperative prediction of lymph node metastasis in lung adenocarcinoma based on tumor size and carcinoembryonic antigen.Journal of thoracic disease · 2026Article
- Artificial Intelligence-Based 18F-FDG PET/CT Radiomics for Mediastinal Lymph Node Staging in Non-Small Cell Lung Cancer: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Dual-mode 3D shear wave elastography with qualitative and quantitative assessment improves diagnosis of inguinal lymph node metastasis.Quantitative imaging in medicine and surgery · 2026Article
- Predictive value of primary tumorCancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Interpretable Deep Learning with Multi-Scale CT for Predicting Occult Lymph Node Metastasis in Early-Stage NSCLC: A Multicenter Study.Journal of imaging informatics in medicine · 2026Article
- Imaging of Small Lung Nodules on Modern SAFOV and LAFOV PET in Combination With Data-driven Motion Correction: Implications for Current Practice.Clinical nuclear medicine · 2026Article
- Clinical added value of LAFOV PET/CT in patients undergoing same-day [18 F]FDG SAFOV PET/CT scans: an initial experience report and explorative study.European journal of nuclear medicine and molecular imaging · 2026Article
- [European journal of nuclear medicine and molecular imaging · 2026Article
- Lesion conspicuity by size in [EJNMMI research · 2026Article
- Fibroblast activation Protein-Targeted PET/CT using [18 F]FAP-2286 for the evaluation of lung cancer: A comparative study with [18 F]FDG PET/CT.European journal of nuclear medicine and molecular imaging · 2026Article
- Long Axial Field-of-view PET: A New Era of Quantitative PET Imaging for Theranostic Applications in Clinic.PET clinics · 2025Review
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12 authors.
Funding
Abstract
introductionOur aim was to characterize the diagnostic accuracy indices for nodal (N)-staging with [
methodsIn this prospective single center cross-over head-to-head comparative study 48 patients underwent [
resultsTB and SAFOV PET/CT showed high diagnostic accuracy indices for patient-based N-staging. Sensitivity and specificity were 86.0% (CI: 77.0-95.0%) and 98.3% (CI: 97.3-99.3%) for TB; 77.2% (CI: 66.3-88.1%) and 97.4% (CI: 96.1-98.6%) for SAFOV PET. Positive predictive value was higher for TB (81.7%, CI: 71.9-91.5%) compared to SAFOV PET (72.1%, CI: 60.9-83.4%). However, this finding was not statistically significant (p = 0.08). Negative predictive values for TB (98.6%, CI: 97.9-99.6%) and SAFOV PET/CT (98.0%, CI: 96.9-99.1%) were comparable. Overall, NSCLC N-staging was affected in six cases on SAFOV and only in one case on TB PET/CT. Semi-quantitative analysis revealed a threshold of SUV
conclusionTB and SAFOV PET/CT showed high diagnostic accuracy indices for N-staging in NSCLC patients. Sensitivity and PPV on TB PET/CT were slightly higher, compared to SAFOV PET/CT without statistical significance. However, TB PET/CT showed lower rate of incorrect N-staging and lower semi-quantitative thresholds for the detection positive mediastinal lymph nodes. Therefore, TB PET/CT might be advantageous in detecting small and low [
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