Evidence map›Paper›PMID 40113516›Full record

ArticleTrends in microbiology2025

Solidification of protein aggregates deepens bacterial dormancy.

Katherine J Sniezek, Nashaly Soto-Echevarria, Mark P Brynildsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Katherine J SniezekDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.
Nashaly Soto-EchevarriaDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Mark P BrynildsenDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA; Department of Molecular Biology, Princeton University, Princeton, NJ, USA; Omenn-Darling Bioengineering Institute, Princeton University, Princeton, NJ, USA. Electronic address: mbrynild@princeton.edu.

Funding

Investigating ploidy modulation as a strategy to improve antibiotic activityR21AI182745 · NIAID · PRINCETON UNIVERSITY · PI BRYNILDSEN, MARK P · 2024 to 2025
$450k
NIAID NIH HHS R21 AI182745
6 · The paper itself

Abstract

Bacteria can exist in different states of dormancy, with persisters and viable-but-nonculturable cells (VBNCs) constituting two modes thought to contribute to infections. Recently, Bollen and colleagues discovered that the state of protein aggregates inside cells impacts the depth of dormancy in individual bacteria, with solidification pushing them further into quiescence.

Indexed as

BacteriaBacterial ProteinsProtein AggregatesMicrobial ViabilityBacterial ProteinsProtein Aggregatesbiomolecular condensateDnaKpersisterphase transitionVBNC

Identifiers

PMID40113516
PMCPMC12068556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.