Evidence map›Paper›PMID 40113485›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

Modulation of ZnT-1 by Let7a unveils a therapeutic potential in amyotrophic lateral sclerosis.

Serenella Anzilotti, Cristina Franco, Valeria Valsecchi, Ornella Cuomo, Giovanna Lombardi, Noemi Di Muraglia, Nunzia De Iesu, Giusy Laudati, Lucio Annunziato, Lorella Maria Teresa Canzoniero and 1 more

Abstract read
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In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Serenella AnzilottiDepartment of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy; Department of Science and Technology, University of Sannio, Benevento, Italy.
Cristina FrancoDepartment of Science and Technology, University of Sannio, Benevento, Italy.
Valeria ValsecchiDivision of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University of Naples Federico II, Naples, Italy.
Ornella CuomoDivision of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University of Naples Federico II, Naples, Italy.
Giovanna LombardiDivision of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University of Naples Federico II, Naples, Italy.
Noemi Di MuragliaInternational School of Advanced Studies, University of Camerino, Camerino, Italy.
Nunzia De IesuIRCCS Synlab SDN S.p.A, Naples, Italy.
Giusy LaudatiDivision of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University of Naples Federico II, Naples, Italy.
Lucio AnnunziatoIRCCS Synlab SDN S.p.A, Naples, Italy.
Lorella Maria Teresa CanzonieroDepartment of Science and Technology, University of Sannio, Benevento, Italy.
Giuseppe PignataroDivision of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University of Naples Federico II, Naples, Italy. Electronic address: giuseppe.pignataro@unina.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The imbalance in cellular ionic homeostasis represents a hallmark of several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS). Zinc Transporter 1 (ZnT1), the first described member of the ZnT family, stands out as the sole member of the SLC30 family responsible for exporting cytosolic zinc to the extracellular space. While ZnT1 is expressed across all tissues and cell types studied, it exhibits the highest prominence within the central nervous system. In ALS SOD1

Indexed as

Amyotrophic Lateral SclerosisCation Transport ProteinsMicroRNAsAnimalsDisease Models, AnimalHumansMiceMice, TransgenicMicrogliaMotor NeuronsSpinal CordSuperoxide DismutaseCation Transport ProteinsMicroRNAsSuperoxide DismutaseALSG93AmicroRNAZnT1

Identifiers

PMID40113485
PMCPMC12047506

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.