Evidence map›Paper›PMID 40113223›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning.

Carlos Vinícius Gomes, Yizhou Chen, Isabel Rauscher, Song Xue, Andrei Gafita, Jiaxi Hu, Robert Seifert, Lorenzo Mercolli, Julia Brosch-Lenz, Jimin Hong and 7 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Applications of artificial intelligence in nuclear medicine.Zeitschrift fur medizinische Physik · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. EJNMMI physics · 2025
    Article
  10. Review
  11. Review
  12. Lesion Absorbed Dose-Response Relationship in Patients with Metastatic Castration-Resistant Prostate Cancer Undergoing [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Carlos Vinícius GomesDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Yizhou ChenDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Isabel RauscherDepartment of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany.
Song XueDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Andrei GafitaDepartment of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany.
Jiaxi HuDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Robert SeifertDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Lorenzo MercolliDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Julia Brosch-LenzDepartment of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany.
Jimin HongDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Marc RyhinerDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Sibylle ZieglerDepartment of Nuclear Medicine, Hannover Medical School (MHH), Hannover, Germany.
Ali Afshar-OromiehDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Matthias EiberDepartment of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany.
Thiago Viana Miranda LimaInstitute of Radiology and Nuclear Medicine, Lucerne University Teaching and Research Hospital, Lucerne, Switzerland.
Kuangyu ShiDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; kuangyu.shi@unibe.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-time-point (STP) image-based dosimetry offers a more convenient approach for clinical practice in radiopharmaceutical therapy (RPT) compared with conventional multiple-time-point image-based dosimetry. Despite numerous advancements, current STP methods are limited by the need for strict and late timing in data acquisition, posing challenges in routine clinical settings. This study introduces a new concept of instant STP (iSTP) dosimetry, achieved by predicting the effective half-life (

Indexed as

Machine LearningRadiometryAgedHalf-LifeHumansMaleMiddle AgedRadiopharmaceuticalsTime FactorsRadiopharmaceuticals[177Lu]Lu-PSMA I&Tdosimetrymachine learningradiopharmaceutical therapysingle time point

Identifiers

PMID40113223
PMCPMC12051766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.