Evidence map›Paper›PMID 40113042›Full record

ArticleThe Journal of biological chemistry2025

Ninein isoform contributions to intracellular processes and macrophage immune function.

Safia Omer, Elizabeth Persaud, Safia Mohammad, Bolu Ayo-Farinloye, Rebecca E Heineman, Emily Wellwood, G Adam Mott, Rene E Harrison

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Safia OmerDepartment of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, USA.
Elizabeth PersaudDepartment of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, USA.
Safia MohammadDepartment of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, USA.
Bolu Ayo-FarinloyeDepartment of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, USA.
Rebecca E HeinemanDepartment of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, USA.
Emily WellwoodDepartment of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, USA.
G Adam MottDepartment of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, USA.
Rene E HarrisonDepartment of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, USA. Electronic address: rene.harrison@utoronto.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ninein is a multifunctional protein involved in microtubule (MT) organization and dynein/dynactin complex recruitment and activation. Several isoforms of ninein have been identified in various tissues, however, their relative contribution(s) are not clear. Here, we identify two ninein isoforms in mouse macrophages with distinct C-termini and disproportionate expression levels; a canonical ninein (ninein

Indexed as

Cytoskeletal ProteinsMacrophagesMicrotubule-Associated ProteinsAlternative SplicingAnimalsCell ProliferationCentrosomeHumansMiceMicrotubulesProtein IsoformsCytoskeletal ProteinsMicrotubule-Associated ProteinsProtein Isoformscentrosome cohesiondynein adaptorsisoforms and differential functionsmicrotubule organizationphagocytosis

Identifiers

PMID40113042
PMCPMC12135376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.