Evidence map›Paper›PMID 40112945›Full record

ArticleExperimental eye research2025

Lysophosphatidic acid receptor 3 (LPAR3) regulates ocular surface chloride transport via calcium signaling.

Ethan S Lindgren, Rongshan Yan, Yien-Ming Kuo, Qi Gao, Livia de Souza Goncalves, Feeling Y Chen, Matilda F Chan, Alan S Verkman, Onur Cil, Neel D Pasricha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ethan S LindgrenDepartment of Ophthalmology, University of California, San Francisco, USA.
Rongshan YanDepartment of Ophthalmology, University of California, San Francisco, USA.
Yien-Ming KuoDepartment of Ophthalmology, University of California, San Francisco, USA.
Qi GaoDepartment of Pediatrics, University of California, San Francisco, USA.
Livia de Souza GoncalvesDepartment of Pediatrics, University of California, San Francisco, USA.
Feeling Y ChenDepartment of Cell & Tissue Biology, University of California, San Francisco, USA.
Matilda F ChanDepartment of Ophthalmology, University of California, San Francisco, USA; Francis I. Proctor Foundation, University of California, San Francisco, USA.
Alan S VerkmanDepartments of Medicine and Physiology, University of California, San Francisco, USA.
Onur CilDepartment of Pediatrics, University of California, San Francisco, USA.
Neel D PasrichaDepartment of Ophthalmology, University of California, San Francisco, USA; Francis I. Proctor Foundation, University of California, San Francisco, USA. Electronic address: neel.pasricha@ucsf.edu.

Funding

SLC26A3 (DRA) Inhibitors for Treatment of Hyperoxaluria and NephrolithiasisR01DK126070 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CIL, ONUR · 2020 to 2024
$1.6M
Roles of CaSR in ocular surface health and diseaseR01EY036139 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Onur Cil · 2024 to 2026
$1.2M
NEI NIH HHS R01 EY036139NIDDK NIH HHS R01 DK126070
6 · The paper itself

Abstract

Dry eye is a multifactorial disease associated with impaired tear film homeostasis, damaging the ocular surface epithelium. Lysophosphatidic acid receptors (LPARs) are G-protein coupled receptors involved in Ca

Indexed as

Calcium SignalingChloridesConjunctivaDry Eye SyndromesEpithelium, CornealReceptors, Lysophosphatidic AcidAnimalsCells, CulturedFemaleHumansLacrimal ApparatusMaleMiceMice, Inbred C57BLTearsChloridesReceptors, Lysophosphatidic AcidCalcium-activated chloride channelsChloride transportDry eye diseaseIntracellular calcium

Identifiers

PMID40112945
PMCPMC13011502

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.