ArticleCell2025
Jumbo phage killer immune system targets early infection of nucleus-forming phages.
Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The bacteriophage transcription factor Gp53 suppresses cell division and regulates Pseudomonas aeruginosa physiology.Communications biology · 2026Article
- How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026Review
- Bacteriophages Control Epiphytic Pseudomonas syringae Populations in Highbush Blueberry Leaves.Microbial biotechnology · 2026Article
- Recent Advances in the Molecular Mechanisms of Bacterial Anti-Phage Defence Systems.Microbial biotechnology · 2026Article
- Review
- Article
- The biology of jumbo phages.Nature communications · 2026Review
- Isolation, characterization and biocontrol of a novel bacteriophage against Ralstonia pseudosolanacearum.Applied microbiology and biotechnology · 2026Article
- Structural atlas of the intact jumbo phage phiKZ.Nature communications · 2026Article
- Molecular basis for anti-jumbo phage immunity by AVAST type 5.Molecular cell · 2026Article
- Phage cocktails containing a dual-receptorApplied and environmental microbiology · 2026Article
- A methylome-derived mbioRxiv : the preprint server for biology · 2026Article
- Bacteriophage genome-wide transposon mutagenesis.bioRxiv : the preprint server for biology · 2025Article
- More Is Not Always Better: Co-Occurrence Analysis of Anti-Phage Systems Reveals Prevalent Neutral Interactions inMicroorganisms · 2025Article
- The complex developmental mechanisms of nucleus-forming jumbo phages.Current opinion in microbiology · 2025Review
- Licence to knockdown - the phage gene silencer.Nature reviews. Microbiology · 2025Article
- Characterization of a novel Jumbo phage JP4 with potential to control pathogenic Escherichia coli.Virology journal · 2025Article
- Jumbo phage-mediated transduction of genomic islands.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Therapeutic application of a jumbo bacteriophage against metallo-β-lactamase producing Pseudomonas aeruginosa clinical isolates.Journal of biomedical science · 2025Article
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Authors and funding
18 authors.
Funding
Abstract
Jumbo bacteriophages of the ϕKZ-like family assemble a lipid-based early phage infection (EPI) vesicle and a proteinaceous nucleus-like structure during infection. These structures protect the phage from nucleases and may create selective pressure for immunity mechanisms targeting this specific phage family. Here, we identify "jumbo phage killer" (Juk), a two-component immune system that terminates infection of ϕKZ-like phages, suppressing the expression of early phage genes and preventing phage DNA replication and phage nucleus assembly while saving the cell. JukA (formerly YaaW) rapidly senses the EPI vesicle by binding to an early-expressed phage protein, gp241, and then directly recruits JukB. The JukB effector structurally resembles a pore-forming toxin and destabilizes the EPI vesicle. Functional anti-ϕKZ JukA homologs are found across bacterial phyla, associated with diverse effectors. These findings reveal a widespread defense system that specifically targets early events executed by ϕKZ-like jumbo phages prior to phage nucleus assembly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.