Evidence map›Paper›PMID 40112330›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Diagnostic journey and management of patients with mild cognitive impairment and Alzheimer's disease dementia: A multinational, real-world survey.

Simona Z Vasileva-Metodiev, Drew Spargo, Eric G Klein, Frances-Catherine Quevenco, Sarah Cotton, Pascual Sanchez-Juan, Yoshiki Niimi, Nicole R Fowler

Abstract readMulticenter Study
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Simona Z Vasileva-MetodievEli Lilly & Company, Indianapolis, IN, USA.ORCID 0000-0003-2043-5661
Drew SpargoEli Lilly & Company, Indianapolis, IN, USA.ORCID 0000-0002-4460-9614
Eric G KleinEli Lilly & Company, Indianapolis, IN, USA.ORCID 0009-0001-3852-5537
Frances-Catherine QuevencoEli Lilly & Company, Indianapolis, IN, USA.ORCID 0000-0003-1467-6880
Sarah CottonAdelphi Real World, Bollington, UK.ORCID 0000-0003-1158-6345
Pascual Sanchez-JuanAlzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Madrid, Spain.
Yoshiki NiimiUnit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo, Japan.ORCID 0000-0002-2556-8167
Nicole R FowlerDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-6465-0008

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundAn Alzheimer's disease (AD) diagnosis made in the earliest symptomatic stages substantially benefits patients and their care partners. However, little is known regarding the clinical, healthcare system-level, and patient-specific barriers that hinder timely diagnosis and treatment.ObjectiveTo explore real-world practices surrounding the diagnostic journey and management of mild cognitive impairment (MCI)/AD dementia patients.MethodsData were drawn from Adelphi Real World Dementia Disease Specific Programme™, a cross-sectional survey of physicians treating MCI/AD dementia patients in France, Germany, Italy, Spain, the United Kingdom, the United States, and Japan between 2022 and 2024.ResultsOverall, 779 physicians reported data on 5551 patients. Physicians indicated current disease severity for 5421 patients; 37.2% had MCI (87.3% with suspected prodromal AD and 12.7% undetermined etiology), 17.2% AD with mild dementia, 31.1% AD with moderate dementia, and 14.5% AD with severe dementia. When not immediately diagnosed

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAged, 80 and overCross-Sectional StudiesDisease ManagementFemaleHumansMaleSurveys and QuestionnairesUnited StatesAlzheimer's diseasebiomarkercare managementdementia diagnosisdiagnostic testinghealthcare systemmild cognitive impairmentpatient journeyreal worldreferraltimely diagnosis

Identifiers

PMID40112330
PMCPMC12231793

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.